11 results

Using immersive tech to enrich healthcare education

Digital Artefact
McKenzie, C., Skinner, J., & Poole, A. Using immersive tech to enrich healthcare education. [Article]

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McKenzie, C., Skinner, J., & Poole, A. Using immersive tech to enrich healthcare education. [Article]
As virtual reality technology has become more affordable and user friendly, it opens opportunities to enhance teaching of clinical skills. Here’s how one team brings VR into t...

Precision Medicine and the Role of Biomarkers of Radiotherapy Response in Breast Cancer

Journal Article
Meehan, J., Gray, M., Martínez-Pérez, C., Kay, C., Pang, L. Y., Fraser, J. A., …Turnbull, A. K. (2020)
Precision Medicine and the Role of Biomarkers of Radiotherapy Response in Breast Cancer. Frontiers in Oncology, 10, https://doi.org/10.3389/fonc.2020.00628
Radiotherapy remains an important treatment modality in nearly two thirds of all cancers, including the primary curative or palliative treatment of breast cancer. Unfortunatel...

hASH1 nuclear localization persists in neuroendocrine transdifferentiated prostate cancer cells, even upon reintroduction of androgen

Journal Article
Fraser, J. A., Sutton, J. E., Tazayoni, S., Bruce, I., & Poole, A. V. (2019)
hASH1 nuclear localization persists in neuroendocrine transdifferentiated prostate cancer cells, even upon reintroduction of androgen. Scientific Reports, 9, https://doi.org/10.1038/s41598-019-55665-y
Neuroendocrine prostate cancer (NEPC) is thought to arise as prostate adenocarcinoma cells transdifferentiate into neuroendocrine (NE) cells to escape potent anti-androgen the...

Preferential activation of HIF-2α adaptive signalling in neuronal-like cells in response to acute hypoxia

Journal Article
Martín-Aragón Baudel, M. A. S., Rae, M. T., Darlison, M. G., Poole, A. V., & Fraser, J. A. (2017)
Preferential activation of HIF-2α adaptive signalling in neuronal-like cells in response to acute hypoxia. PLOS ONE, 12(10), https://doi.org/10.1371/journal.pone.0185664
Stroke causes severe neuronal damage as disrupted cerebral blood flow starves neurons of oxygen and glucose. The hypoxia inducible factors (HIF-1α and HIF-2α) orchestrate oxyg...

Preferential activation of HIF-2 adaptive mechanisms in neuronal-like cells in response to hypoxia

Presentation / Conference
Fraser, J., Baudel, M., Rae, M., Darlison, M., & Poole, A. (2017, April)
Preferential activation of HIF-2 adaptive mechanisms in neuronal-like cells in response to hypoxia. Poster presented at British Neuroscience Association - festival of neuroscience 2017
Stroke is a leading cause of death and disability worldwide. Blockage, or occlusion, of cerebral arteries causes irreversible neuronal damage as disrupted blood flow starves n...

The expression of the chloride co-transporters NKCC1 and KCC2 is reversed in the penumbra following

Conference Proceeding
Baudel, M., Rae, M., Fraser, J., & Poole, A. (2017)
The expression of the chloride co-transporters NKCC1 and KCC2 is reversed in the penumbra following. In Brain and Neuroscience: BNA 2017 Festival of Neuroscience: Abstract Book
Stroke is one of the major causes of death and disability worldwide. The harm caused by the interruption of blood flow to the brain unfolds in the subsequent hours and days, s...

Chloride co-transporters as possible therapeutic targets for stroke

Journal Article
Martín-Aragón Baudel, M. A. S., Martín-Aragón Baudel, M. A. S., Poole, A. V., & Darlison, M. G. (2017)
Chloride co-transporters as possible therapeutic targets for stroke. Journal of Neurochemistry, 140(2), 195-209. https://doi.org/10.1111/jnc.13901
Stroke is one of the major causes of death and disability worldwide. The major type of stroke is an ischaemic one, which is caused by a blockage that interrupts blood flow to...

Investigating the molecular mechanisms driving neuroendocrine differentiation in androgen deprived prostate cancer cells

Conference Proceeding
Sutton, J., Hutchison, G., Fraser, J., & Poole, A. (2016)
Investigating the molecular mechanisms driving neuroendocrine differentiation in androgen deprived prostate cancer cells
Background: Neuroendocrine differentiation is commonplace in prostate tumors treated with androgen deprivation therapy and is associated with castrate-resistant disease progre...

Design and evaluation of novel theranostic fluorogenic dual probe-prodrug in cancer

Journal Article
Mathur, S., Mincher, D., Turnbull, A., Stevens, C., & Poole, A. (2016)
Design and evaluation of novel theranostic fluorogenic dual probe-prodrug in cancer. European Journal of Cancer, 61, S142. https://doi.org/10.1016/s0959-8049%2816%2961501-0
Background: In spite of major advances in the diagnosis and treatment of cancer, there remains a paucity of biomarkers for early detection. Legumain is a potential cancer biom...

GABAA receptor chloride channels are involved in the neuroprotective role of GABA following oxygen and glucose deprivation in the rat cerebral cortex but not in the hippocampus

Journal Article
Darlison, M. G., Dos-Anjos, S., Llorente, I. L., Llorente, I. L., Perez-Rodriguez, D., Martínez-Villayandre, B., …Fernández-López, A. (2013)
GABAA receptor chloride channels are involved in the neuroprotective role of GABA following oxygen and glucose deprivation in the rat cerebral cortex but not in the hippocampus. Brain Research, 1533, 141-151. https://doi.org/10.1016/j.brainres.2013.08.024
Assays on "ex vivo" sections of rat hippocampus and rat cerebral cortex, subjected to oxygen and glucose deprivation (OGD) and a three-hour reperfusion-like (RL) recovery, wer...
10 results

Evaluating the effects of air pollution derived toxic nanoparticles on astrocyte reactivity and neurodegeneration

2021 - date
Beatrice Villani | Director of Studies: Dr Fiona Kerr | Second Supervisor: Dr Amy Poole

The effects of parasites on food web structure and dynamics: new ways to improve accuracy and ecological realism

2021 - date
Tully Osmond | Director of Studies: Dr Luke Holman

Exploring restorative justice for adults in Scotland: Practitioners’ views, organisational models and policy

2019 - 2021
Siobhan Butler | Director of Studies: Dr Giuseppe Maglione | Second Supervisor: Dr Jamie Buchan

Analysing the molecular mechanisms of cell migration inhibition in response to honokiol

2019 - 2021
Ying Lei | Director of Studies: Dr Sharron Vass | Second Supervisor: Dr Amy Poole

Exosomes as mediators of cell to-cell communication in prostate cancer

2018 - 2021
Isla Bruce | Director of Studies: Dr Amy Poole | Second Supervisor: Dr Jenny Fraser

Investigating the sex-specific legacy of excessive fetal androgen exposure on immune function and hepatic health

2017 - date
Jennifer Mcgeachie | Director of Studies: Prof Mick Rae | Second Supervisor: Dr Amy Poole

Characterisation of GABAA receptors and cation-chrloride cotransporters in the uterus and their role in pre-term labour

2015 - 2018
Melissa Sutherland | Director of Studies: Dr Amy Poole | Second Supervisor: Dr Jenny Fraser

The role of the human cathelicidin LL-37 in rhinovirus infection

2014 - 2019
The PhD project which I am undertaking is focused on understanding the role of cathelicidins during respiratory viral infections. Cathel...
Dr Filipa Henderson Sousa | Director of Studies: Prof Peter Barlow | Second Supervisor: Dr Craig Stevens

Assessment of trophic polymorphism in the Himalayan fish Tor putitora

2013 - 2022
Ian Martin | Director of Studies: Prof Robert Briers | Second Supervisor: Dr Sonja Rueckert

The role of gamma-aminobutyric acid type A (GABA-A) receptor and cation chloride co-transporters (CCCs) as possible neuroprotective targets in stroke

2013 - 2018
This doctoral research project is concerned with th...
Miguel Ángel Stanislas Martín-Aragón Baudel | Director of Studies: Dr Amy Poole | Second Supervisor: Dr Jenny Fraser

Date


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