Pre-validation of a reporter gene assay for oxidative stress for the rapid screening of nanobiomaterials
Journal Article
Martin, S., de Haan, L., Miro Estruch, I., Eder, K. M., Marzi, A., Schnekenburger, J., …Bouwmeester, H. (2022)
Pre-validation of a reporter gene assay for oxidative stress for the rapid screening of nanobiomaterials. Frontiers in Toxicology, 4, Article 974429. https://doi.org/10.3389/ftox.2022.974429
Engineered nanomaterials have been found to induce oxidative stress. Cellular oxidative stress, in turn, can result in the induction of antioxidant and detoxification enzymes ...
Physiological characteristics and performance in elite enduro mountain biking
Journal Article
Kirkwood, L., Ingram, L., Cunningham, J., Malone, E., & Florida-James, G. (2017)
Physiological characteristics and performance in elite enduro mountain biking. Journal of Science and Cycling, 6(2), 13-21. https://doi.org/10.28985/171231.jsc.09
Enduro mountain bike racing is composed of several timed predominantly downhill race stages linked by time restricted, non-competitive transition stages. This study aimed to ...
Vascular Ageing and Exercise: Focus on Cellular Reparative Processes
Journal Article
Ross, M. D., Malone, E., & Florida-James, G. (2016)
Vascular Ageing and Exercise: Focus on Cellular Reparative Processes. Oxidative Medicine and Cellular Longevity, 2016, 1-15. https://doi.org/10.1155/2016/3583956
Ageing is associated with an increased risk of developing noncommunicable diseases (NCDs), such as diabetes and cardiovascular disease (CVD). The increased risk can be attribu...
How can scientists and designers find ways of working together? A case study of playful learning to co-design visual interpretations of immunology concepts
Journal Article
Macdonald, I., Malone, E., & Firth, R. (2022)
How can scientists and designers find ways of working together? A case study of playful learning to co-design visual interpretations of immunology concepts. Studies in Higher Education, 47(9), 1980-1996. https://doi.org/10.1080/03075079.2021.2020745
In UK HE institutions there is a growing realisation and appreciation for academic disciplines to seek research partners beyond their own subject (QAA. 2018. Enterprise and en...
Immune Response of Elite Enduro Racers to Laboratory and Racing Environments: The Influence of Training Impulse and Vibration
Journal Article
Kirkwood, L., Ingram-Sills, L., Taylor, M. D., Malone, E., & Florida-James, G. (2021)
Immune Response of Elite Enduro Racers to Laboratory and Racing Environments: The Influence of Training Impulse and Vibration. International Journal of Environmental Research and Public Health, 18(9), https://doi.org/10.3390/ijerph18094603
Introduction: Understanding the sport-specific immune response elicited during both training and competition is imperative to maximise athlete health and performance. Despite ...
Lower Resting and Exercise-Induced Circulating Angiogenic Progenitors and Angiogenic T-Cells in Older Men
Journal Article
Ross, M. D., Malone, E. M., Simpson, R., Cranston, I., Ingram, L., Wright, G. P., …Florida-James, G. D. (2018)
Lower Resting and Exercise-Induced Circulating Angiogenic Progenitors and Angiogenic T-Cells in Older Men. American journal of physiology. Heart and circulatory physiology, 314(3), 392-402. https://doi.org/10.1152/ajpheart.00592.2017
Ageing is associated with a dysfunctional endothelial phenotype, as well as reduced angiogenic capabilities. Exercise exerts beneficial effects on the cardiovascular system, p...
Sleep disruption and its effect on lymphocyte redeployment following an acute bout of exercise
Journal Article
Florida-James, G. D., Ingram, L. A., Simpson, R. J., Malone, E., & Florida-James, G. (2015)
Sleep disruption and its effect on lymphocyte redeployment following an acute bout of exercise. Brain, Behavior, and Immunity, 47, 100-108. https://doi.org/10.1016/j.bbi.2014.12.018
Sleep disruption and deprivation are common in contemporary society and have been linked with poor health, decreased job performance and increased life-stress. The rapid redep...
Older men display elevated levels of senescence-associated exercise-responsive CD28null angiogenic T cells compared with younger men
Journal Article
Ross, M., Ingram, L., Taylor, G., Malone, E., Simpson, R. J., West, D., & Florida-James, G. (2018)
Older men display elevated levels of senescence-associated exercise-responsive CD28null angiogenic T cells compared with younger men. Physiological Reports, 6(12), 1-11. https://doi.org/10.14814/phy2.13697
Aging is associated with elevated cardiovascular disease risk. As a result of aging, endothelial dysfunction develops, partly due to a reduction in vascular regenerative abili...
Removal of regulatory T cell activity reverses hyporesponsiveness and leads to filarial parasite clearance in vivo.
Journal Article
Taylor, M. D., LeGoff, L., Harris, A., Malone, E. M., Allen, J. E., & Maizels, R. M. (2005)
Removal of regulatory T cell activity reverses hyporesponsiveness and leads to filarial parasite clearance in vivo. Journal of Immunology, 174, 4924-4933
Human filarial parasites cause chronic infection associated with long-term down-regulation of the host’s immune response. We show here that CD4+ T cell regulation is the main ...
A 10 km time trial running bout acutely increases the number of angiogenic T cells in the peripheral blood compartment of healthy males: Acute exercise mobilizes angiogenic T cells
Journal Article
Ross, M., Tormey, P., Ingram, L., Simpson, R., Malone, E., & Florida-James, G. (2016)
A 10 km time trial running bout acutely increases the number of angiogenic T cells in the peripheral blood compartment of healthy males: Acute exercise mobilizes angiogenic T cells. Experimental Physiology, 101(10), 1253-1264. https://doi.org/10.1113/ep085771
New Findings
What is the central question of the study?
Are CD31+ angiogenic T (TANG) cells preferentially mobilized in response to acute exercise?
What is the main finding an...