Using immersive tech to enrich healthcare education
Digital Artefact
McKenzie, C., Skinner, J., & Poole, A. Using immersive tech to enrich healthcare education. [Article])
McKenzie, C., Skinner, J., & Poole, A. Using immersive tech to enrich healthcare education. [Article]
As virtual reality technology has become more affordable and user friendly, it opens opportunities to enhance teaching of clinical skills. Here’s how one team brings VR into t...
Precision Medicine and the Role of Biomarkers of Radiotherapy Response in Breast Cancer
Journal Article
Meehan, J., Gray, M., Martínez-Pérez, C., Kay, C., Pang, L. Y., Fraser, J. A., …Turnbull, A. K. (2020)
Precision Medicine and the Role of Biomarkers of Radiotherapy Response in Breast Cancer. Frontiers in Oncology, 10, https://doi.org/10.3389/fonc.2020.00628
Radiotherapy remains an important treatment modality in nearly two thirds of all cancers, including the primary curative or palliative treatment of breast cancer. Unfortunatel...
hASH1 nuclear localization persists in neuroendocrine transdifferentiated prostate cancer cells, even upon reintroduction of androgen
Journal Article
Fraser, J. A., Sutton, J. E., Tazayoni, S., Bruce, I., & Poole, A. V. (2019)
hASH1 nuclear localization persists in neuroendocrine transdifferentiated prostate cancer cells, even upon reintroduction of androgen. Scientific Reports, 9, https://doi.org/10.1038/s41598-019-55665-y
Neuroendocrine prostate cancer (NEPC) is thought to arise as prostate adenocarcinoma cells transdifferentiate into neuroendocrine (NE) cells to escape potent anti-androgen the...
Preferential activation of HIF-2α adaptive signalling in neuronal-like cells in response to acute hypoxia
Journal Article
Martín-Aragón Baudel, M. A. S., Rae, M. T., Darlison, M. G., Poole, A. V., & Fraser, J. A. (2017)
Preferential activation of HIF-2α adaptive signalling in neuronal-like cells in response to acute hypoxia. PLOS ONE, 12(10), https://doi.org/10.1371/journal.pone.0185664
Stroke causes severe neuronal damage as disrupted cerebral blood flow starves neurons of oxygen and glucose. The hypoxia inducible factors (HIF-1α and HIF-2α) orchestrate oxyg...
Preferential activation of HIF-2 adaptive mechanisms in neuronal-like cells in response to hypoxia
Presentation / Conference
Fraser, J., Baudel, M., Rae, M., Darlison, M., & Poole, A. (2017, April)
Preferential activation of HIF-2 adaptive mechanisms in neuronal-like cells in response to hypoxia. Poster presented at British Neuroscience Association - festival of neuroscience 2017
Stroke is a leading cause of death and disability worldwide. Blockage, or occlusion, of cerebral arteries causes irreversible neuronal damage as disrupted blood flow starves n...
The expression of the chloride co-transporters NKCC1 and KCC2 is reversed in the penumbra following
Conference Proceeding
Baudel, M., Rae, M., Fraser, J., & Poole, A. (2017)
The expression of the chloride co-transporters NKCC1 and KCC2 is reversed in the penumbra following. In Brain and Neuroscience: BNA 2017 Festival of Neuroscience: Abstract Book
Stroke is one of the major causes of death and disability worldwide. The harm caused by the interruption of blood flow to the brain unfolds in the subsequent hours and days, s...
Chloride co-transporters as possible therapeutic targets for stroke
Journal Article
Martín-Aragón Baudel, M. A. S., Martín-Aragón Baudel, M. A. S., Poole, A. V., & Darlison, M. G. (2017)
Chloride co-transporters as possible therapeutic targets for stroke. Journal of Neurochemistry, 140(2), 195-209. https://doi.org/10.1111/jnc.13901
Stroke is one of the major causes of death and disability worldwide. The major type of stroke is an ischaemic one, which is caused by a blockage that interrupts blood flow to...
Investigating the molecular mechanisms driving neuroendocrine differentiation in androgen deprived prostate cancer cells
Conference Proceeding
Sutton, J., Hutchison, G., Fraser, J., & Poole, A. (2016)
Investigating the molecular mechanisms driving neuroendocrine differentiation in androgen deprived prostate cancer cells
Background: Neuroendocrine differentiation is commonplace in prostate tumors treated with androgen deprivation therapy and is associated with castrate-resistant disease progre...
Design and evaluation of novel theranostic fluorogenic dual probe-prodrug in cancer
Journal Article
Mathur, S., Mincher, D., Turnbull, A., Stevens, C., & Poole, A. (2016)
Design and evaluation of novel theranostic fluorogenic dual probe-prodrug in cancer. European Journal of Cancer, 61, S142. https://doi.org/10.1016/s0959-8049%2816%2961501-0
Background: In spite of major advances in the diagnosis and treatment of cancer, there remains a paucity of biomarkers for early detection. Legumain is a potential cancer biom...
GABAA receptor chloride channels are involved in the neuroprotective role of GABA following oxygen and glucose deprivation in the rat cerebral cortex but not in the hippocampus
Journal Article
Darlison, M. G., Dos-Anjos, S., Llorente, I. L., Llorente, I. L., Perez-Rodriguez, D., Martínez-Villayandre, B., …Fernández-López, A. (2013)
GABAA receptor chloride channels are involved in the neuroprotective role of GABA following oxygen and glucose deprivation in the rat cerebral cortex but not in the hippocampus. Brain Research, 1533, 141-151. https://doi.org/10.1016/j.brainres.2013.08.024
Assays on "ex vivo" sections of rat hippocampus and rat cerebral cortex, subjected to oxygen and glucose deprivation (OGD) and a three-hour reperfusion-like (RL) recovery, wer...