Alpha 2 agonists for sedation to produce better outcomes from critical illness (A2B trial): protocol for a mixed-methods process evaluation of a randomised controlled trial
Journal Article
Aitken, L. M., Emerson, L. M., Kydonaki, K., Blackwood, B., Creagh-Brown, B., Lone, N. I., …Walsh, T. S. (2024)
Alpha 2 agonists for sedation to produce better outcomes from critical illness (A2B trial): protocol for a mixed-methods process evaluation of a randomised controlled trial. BMJ Open, 14(4), Article e081637. https://doi.org/10.1136/bmjopen-2023-081637
Introduction: An association between deep sedation and adverse short-term outcomes has been demonstrated although this evidence has been inconsistent. The A2B (alpha-2 agonist...
Alpha 2 agonists for sedation to produce better outcomes from critical illness (A2B Trial): protocol for a multicentre phase 3 pragmatic clinical and cost-effectiveness randomised trial in the UK
Journal Article
Walsh, T. S., Aitken, L. M., McKenzie, C. A., Boyd, J., Macdonald, A., Giddings, A., …Page, V. J. (2023)
Alpha 2 agonists for sedation to produce better outcomes from critical illness (A2B Trial): protocol for a multicentre phase 3 pragmatic clinical and cost-effectiveness randomised trial in the UK. BMJ Open, 13(12), Article e078645. https://doi.org/10.1136/bmjopen-2023-078645
Introduction: Almost all patients receiving mechanical ventilation (MV) in intensive care units (ICUs) require analgesia and sedation. The most widely used sedative drug is pr...
Patients’ experiences and perspectives of post-hospital follow-up care to improve physical recovery for intensive care survivors: A systematic review of qualitative research
Journal Article
Rea, N. M., Neubeck, L., McHale, S., & Kydonaki, K. (2023)
Patients’ experiences and perspectives of post-hospital follow-up care to improve physical recovery for intensive care survivors: A systematic review of qualitative research. International Journal of Nursing Studies Advances, 5, Article 100168. https://doi.org/10.1016/j.ijnsa.2023.100168
Background
Intensive care units deliver care to a heterogeneous group of patients with pre-existing co-morbid disease. Focus has shifted to improving health related quality of...
Understanding the complexities of antibiotic prescribing behaviour in acute hospitals: a systematic review and meta-ethnography
Journal Article
Wojcik, G., Ring, N., McCulloch, C., Willis, D. S., Williams, B., & Kydonaki, K. (2021)
Understanding the complexities of antibiotic prescribing behaviour in acute hospitals: a systematic review and meta-ethnography. Archives of Public Health, 79(1), https://doi.org/10.1186/s13690-021-00624-1
Background: Antimicrobial resistance poses a serious global public health threat. Hospital misuse of antibiotics has
contributed to this problem and evidence-based interventio...
A mixed-methods feasibility study to assess the acceptability and applicability of immersive virtual reality sepsis game as an adjunct to nursing education
Journal Article
Adhikari, R., Kydonaki, C., Lawrie, J., O'Reilly, M., Ballantyne, B., Whitehorn, J., & Paterson, R. (2021)
A mixed-methods feasibility study to assess the acceptability and applicability of immersive virtual reality sepsis game as an adjunct to nursing education. Nurse Education Today, 103, https://doi.org/10.1016/j.nedt.2021.104944
Abstract
Background: Virtual Reality (VR) simulation has been a topic of interest in recent years as an innovative strategy for healthcare education. Although there are a hand...
Inconsistent relationship between depth of sedation and intensive care outcome: systematic review and meta-analysis
Journal Article
Aitken, L. M., Kydonaki, K., Blackwood, B., Trahair, L. G., Purssell, E., Sekhon, M., & Walsh, T. S. (2021)
Inconsistent relationship between depth of sedation and intensive care outcome: systematic review and meta-analysis. Thorax, 76(11), 1089-1098. https://doi.org/10.1136/thoraxjnl-2020-216098
Purpose: To determine the effect of depth of sedation on intensive care mortality, duration of mechanical ventilation, and other clinically important outcomes.
Methods: We s...
Family ward rounds in Intensive Care: an integrative review of the literature
Journal Article
Kydonaki, K., Takashima, M., & Mitchell, M. (2021)
Family ward rounds in Intensive Care: an integrative review of the literature. International Journal of Nursing Studies, 113, https://doi.org/10.1016/j.ijnurstu.2020.103771
Background
The involvement of family members in the ward rounds is a novel but under-researched family-centered care intervention in adult intensive care units, with limited e...
Family INvolvement in inTensive care: A qualitative exploration of critically ill patients, their families and critical care nurses (INpuT study)
Journal Article
Kydonaki, K., Kean, S., & Tocher, J. (2020)
Family INvolvement in inTensive care: A qualitative exploration of critically ill patients, their families and critical care nurses (INpuT study). Journal of Clinical Nursing, 29(7-8), 1115-1128. https://doi.org/10.1111/jocn.15175
Aims and objectives
To understand the different factors that impact on the involvement of adult family members in the care of critically ill patients from the perspective of p...
Challenges and barriers to optimising sedation in intensive care: a qualitative study in eight Scottish intensive care units
Journal Article
Kydonaki, K., Hanley, J., Huby, G., Antonelli, J., & Walsh, T. (2019)
Challenges and barriers to optimising sedation in intensive care: a qualitative study in eight Scottish intensive care units. BMJ Open, 9, https://doi.org/10.1136/bmjopen-2018-024549
Objectives: Various strategies to promote light sedation are highly recommended in recent guidelines, as deep sedation is associated with suboptimum patient outcomes. Yet, the...
Patient and family centered actionable processes of care and performance measures for persistent and chronic critical illness: a systematic review.
Journal Article
Rose, L., Istanboulian, L., Allum, L., Burry, L., Dale, C., Hart, N., …Connolly, B. (2019)
Patient and family centered actionable processes of care and performance measures for persistent and chronic critical illness: a systematic review. Critical Care Explorations, 1(4), https://doi.org/10.1097/CCE.0000000000000005
Objective
To identify actionable processes of care, quality indicators, or performance measures and their evidence base relevant to patients with persistent or chronic critica...