Chemical Genetics Approach to Identify Peptide Ligands that Selectively Stimulate DAPK-1 Kinase Activity
Journal Article
Fraser, J. A., & Hupp, T. R. (2007)
Chemical Genetics Approach to Identify Peptide Ligands that Selectively Stimulate DAPK-1 Kinase Activity. Biochemistry, 46(10), 2655-2673. https://doi.org/10.1021/bi061562j
Dissection of signal transduction pathways has been advanced by classic genetic approaches including targeted gene deletion and siRNA-based inhibition of gene product synthesi...
Carbon black nanoparticles induce type II epithelial cells to release chemotaxins for alveolar macrophages.
Journal Article
Barlow, P. G., Clouter-Baker, A., Donaldson, K., MacCallum, J., & Stone, V. (2005)
Carbon black nanoparticles induce type II epithelial cells to release chemotaxins for alveolar macrophages. Particle and fibre toxicology, 2(1), 11-24. https://doi.org/10.1186/1743-8977-2-11
Background - Alveolar macrophages are a key cell in dealing with particles deposited in the lungs and in determining the subsequent response to that particle exposure. Nanopar...
Oxoazabenzo[de]anthracenes conjugated to Amino Acids: Synthesis and evaluation as DNA-binding antitumor agents.
Journal Article
Dias, N., Goossens, J., Baldeyrou, B., Lansiaux, A., Colson, P., Di Salvo, A., …Bailly, C. (2005)
Oxoazabenzo[de]anthracenes conjugated to Amino Acids: Synthesis and evaluation as DNA-binding antitumor agents. Bioconjugate Chemistry, 16(4), 949-958. https://doi.org/10.1021/bc050065x
We report the synthesis of an original series of oxoazabenzo[de]anthracenes conjugated to an amino acid: Ala, Phe, Pro, Lys, or Gly (4a-e, respectively). The compounds, derive...
Calcium and ROS-mediated activation of transcription factors and TNF-α cytokine gene expression in macrophages exposed to ultrafine particles
Journal Article
Brown, D. M., Donaldson, K., Borm, P. J., Schins, R. P., Dehnhardt, M., Gilmour, P., …Stone, V. (2004)
Calcium and ROS-mediated activation of transcription factors and TNF-α cytokine gene expression in macrophages exposed to ultrafine particles. American Journal of Physiology - Lung Cellular and Molecular Physiology, 286(2), L344-L353. https://doi.org/10.1152/ajplung.00139.2003
Ultrafine (Uf) particles are a component of particulate air pollution suggested to be responsible for the health effects associated with elevations of this pollutant. We have ...
Expression of C-Reactive Protein and Heat-Shock Protein-70 in the Lung Epithelial Cell Line A549, in Response to PM10 Exposure
Journal Article
Ramage, L., & Guy, K. (2004)
Expression of C-Reactive Protein and Heat-Shock Protein-70 in the Lung Epithelial Cell Line A549, in Response to PM10 Exposure. Inhalation Toxicology, 16(6-7), 447-452. https://doi.org/10.1080/08958370490439614
Increased levels of C-reactive protein (CRP) and heat-shock protein-70 (Hsp70) in plasma are known to be associated with an increased risk of cardiovascular disease. In this s...
A preliminary evaluation of the differences in the glycosylation of alpha-1-acid glycoprotein between individual liver diseases.
Journal Article
Anderson, N. E., Pollacchi, A., Hayes, P., Therapondos, G., Newsome, P., Boyter, A. & Smith, K. (2002)
A preliminary evaluation of the differences in the glycosylation of alpha-1-acid glycoprotein between individual liver diseases. Biomedical Chromatography. 16, 365-372. doi:10.1002/bmc.167. ISSN 0269-3879
During the acute phase response (APR) to tissue injury or infection, the liver is responsible for the level of mediators such as cytokines required at the site of inflammation...
Aluminium lactate treatment of DQ12 quartz inhibits its ability to cause inflammation, chemokine expression and NF-kB activation.
Journal Article
Duffin, R., Gilmour, P. S., Schins, R. P. F., Clouter, A., Guy, K., Brown, D. M., …Stone, V. (2001)
Aluminium lactate treatment of DQ12 quartz inhibits its ability to cause inflammation, chemokine expression and NF-kB activation. Toxicology and Applied Pharmacology. 176, 10-17. doi:10.1006/taap.2001.9268. ISSN 0041-008X
In 1997, an IARC Working Group classified quartz (crystalline silica) as a Group 1 lung carcinogen, but only in some industries, i.e., the quartz hazard is a variable entity. ...