Investigating the frequency of senescent T lymphocytes with ageing, exercise and obesity
Thesis
Cosgrove, C. Investigating the frequency of senescent T lymphocytes with ageing, exercise and obesity. (Thesis)
Napier University. Retrieved from http://researchrepository.napier.ac.uk/id/eprint/2491
Cellular senescence is a state of permanent cell cycle arrest in which a cell is unable to further divide in response to normal growth stimuli. Telomere shortening, believed ...
Endochondral Growth Defect and Deployment of Transient Chondrocyte Behaviors Underlie Osteoarthritis Onset in a Natural Murine Model
Journal Article
Staines, K. A., Madi, K., Mirczuk, S. M., Parker, S., Burleigh, A., Poulet, B., …Pitsillides, A. A. (2016)
Endochondral Growth Defect and Deployment of Transient Chondrocyte Behaviors Underlie Osteoarthritis Onset in a Natural Murine Model. Arthritis and Rheumatology, 68(4), 880-891. https://doi.org/10.1002/art.39508
OBJECTIVE:
To explore whether aberrant transient chondrocyte behaviors occur in the joints of STR/Ort mice (which spontaneously develop osteoarthritis [OA]) and whether they a...
The effects of marathon running on expression of the complement regulatory proteins CD55 (DAF) and CD59 (MACIF) on red blood cells.
Journal Article
Simpson, R. J., Florida-James, G., Whyte, G. P., Middleton, N., Shave, R., George, K., & Guy, K. (2007)
The effects of marathon running on expression of the complement regulatory proteins CD55 (DAF) and CD59 (MACIF) on red blood cells. European Journal of Applied Physiology, 99, 201-204. https://doi.org/10.1007/s00421-006-0326-2
Exercise is known to result in the haemolysis of red blood cells (RBCs). Although mechanical stressors such as footstrike and an increased velocity of blood flow may be involv...
Loss of Cell Cycle Checkpoint Control in Drosophila Rfc4 Mutants
Journal Article
Krause, S. A., Loupart, M., Vass, S., Schoenfelder, S., Harrison, S., & Heck, M. M. S. (2001)
Loss of Cell Cycle Checkpoint Control in Drosophila Rfc4 Mutants. Molecular and Cellular Biology, 21(15), 5156-5168. doi:10.1128/mcb.21.15.5156-5168.2001
Two alleles of the Drosophila melanogaster Rfc4(DmRfc4) gene, which encodes subunit 4 of the replication factor C (RFC) complex, cause striking defects in mitotic chromosome c...
The local effects of ovarian diathermy in an ovine model of Polycystic Ovary Syndrome
Journal Article
Shen, W., Connolly, F., Rae, M. T., Butler, M., Klibanov, A. L., Sboros, V., …Duncan, W. C. (2014)
The local effects of ovarian diathermy in an ovine model of Polycystic Ovary Syndrome. PLOS ONE, 9, https://doi.org/10.1371/journal.pone.0111280
In order to develop a medical alternative to surgical ovarian diathermy (OD) in polycystic ovary syndrome (PCOS) more mechanistic information is required about OD. We therefor...
Acute hypotension due to platelet serotonin-induced chemoreflexes after intravenous injection of dextran sulfate in the rabbit
Journal Article
Wiggins, R. C., Glatfelter, A., Campbell, A. M., Kunkel, R. G., & Ulevitch, R. J. (1985)
Acute hypotension due to platelet serotonin-induced chemoreflexes after intravenous injection of dextran sulfate in the rabbit. Circulation Research, 57(2), 262-277. https://doi.org/10.1161/01.res.57.2.262
The hypotension and bradycardia observed after intravenous injection of dextran sulfate in rabbits was prevented by prior depletion of circulating platelets, but was not preve...
A distinctive patchy osteomalacia characterises Phospho1
-deficient mice
Journal Article
-deficient mice. Journal of Anatomy, 231(2), 298-308. https://doi.org/10.1111/joa.12628)
-deficient mice. Journal of Anatomy, 231(2), 298-308. https://doi.org/10.1111/joa.12628
The phosphatase PHOSPHO1 is involved in the initiation of biomineralisation. Bones in Phospho1 KO mice show histological osteomalacia with frequent bowing of long bones and sp...
Phospho1 deficiency transiently modifies bone architecture yet produces consistent modification in osteocyte differentiation and vascular porosity with ageing
Journal Article
Javaheri, B., Carriero, A., Staines, K. A., Chang, Y., Houston, D. A., Oldknow, K. J., …Pitsillides, A. A. (2015)
Phospho1 deficiency transiently modifies bone architecture yet produces consistent modification in osteocyte differentiation and vascular porosity with ageing. Bone, 81, 277-291. https://doi.org/10.1016/j.bone.2015.07.035
PHOSPHO1 is one of principal proteins involved in initiating bone matrix mineralisation. Recent studies have found that Phospho1 KO mice (Phospho1-R74X) display multiple skele...
Immune alterations, lipid peroxidation, and muscle damage following a hill race.
Journal Article
Simpson, R. J., Wilson, M. R., Black, J., Ross, J. A., Whyte, G. P., Guy, K., & Florida-James, G. (2005)
Immune alterations, lipid peroxidation, and muscle damage following a hill race. Applied Physiology, Nutrition, and Metabolism, 30, 196-211. https://doi.org/10.1139/h05-115
Hill races usually include large downhill running sections, which can induce significant degrees of muscle damage in a field setting. This study examined the link between musc...
Effect of instrument attachment on the surface temperature of juvenile grey seals (Halichoerus Grypus) measured by infrared thermography.
Journal Article
McCafferty, D. J., Currie, J. & Sparling, C. E. (2007)
Effect of instrument attachment on the surface temperature of juvenile grey seals (Halichoerus Grypus) measured by infrared thermography. Deep Sea Research Part II Topical Studies in Oceanography. 54, 424-436. doi:10.1016/j.dsr2.2006.11.019
Previous research has highlighted the importance of minimising hydrodynamic drag from biologging instruments fitted to marine mammals. However, there is a need to investigate ...