Antibiotic prescribing: the consequences of getting it wrong
Journal Article
Dancer, S. J. (2016)
Antibiotic prescribing: the consequences of getting it wrong. Clinical Focus Primary Care, 10(2), 62-71
Antibiotics were one of the most important discoveries last century. As with all drugs, however, they are associated with adverse effects. This article reviews how inappropria...
The Roles and Expression of Cationic Host Defence Peptides in Normal and Compromised Pregnancies
Thesis
Coyle, C. (2014)
The Roles and Expression of Cationic Host Defence Peptides in Normal and Compromised Pregnancies. (Thesis). Edinburgh Napier University. Retrieved from http://researchrepository.napier.ac.uk/Output/453010
Cationic Host Defense Peptides (CHDP), also known as antimicrobial peptides, are key components of the host innate immune response that have a wide range of direct microbicida...
Therapeutic potential of Tregs to treat rheumatoid arthritis
Journal Article
Wright, G. P., Stauss, H. J., & Ehrenstein, M. R. (2011)
Therapeutic potential of Tregs to treat rheumatoid arthritis. Seminars in Immunology, 23(3), 195-201. https://doi.org/10.1016/j.smim.2011.07.004
There is accumulating evidence for regulatory T cell defects in rheumatoid arthritis and that some biologic interventions, in particular anti-TNF, can target this population. ...
Natural IgM Is Required for Suppression of Inflammatory Arthritis by Apoptotic Cells
Journal Article
Notley, C. A., Brown, M. A., Wright, G. P., & Ehrenstein, M. R. (2011)
Natural IgM Is Required for Suppression of Inflammatory Arthritis by Apoptotic Cells. The journal of immunology : official journal of the American Association of Immunologists, 186(8), 4967-4972. https://doi.org/10.4049/jimmunol.1003021
The clearance of dying cells is vital for re-establishing tolerance during inflammation and has potent immunoregulatory consequences. Because natural IgM plays a key role in t...
Death-associated protein kinase (DAPK) and signal transduction: additional roles beyond cell death: DAPK and signal transduction
Journal Article
Lin, Y., Hupp, T. R., & Stevens, C. (2009)
Death-associated protein kinase (DAPK) and signal transduction: additional roles beyond cell death: DAPK and signal transduction. FEBS Journal, 277(1), (48-57). ISSN 1742-464X
Death-associated protein kinase (DAPK) is a stress-regulated protein
kinase that mediates a range of processes, including signal-induced cell death and autophagy. Although the...
Autophagy: from basic science to clinical application
Journal Article
Van Limbergen, J., Stevens, C., Nimmo, E. R., Wilson, D. C. & Satsangi, J. (2009)
Autophagy: from basic science to clinical application. Mucosal immunology. 2(4), 315-330. doi:10.1038/mi.2009.20. ISSN 1933-0219
Autophagy is a cellular pathway involved in protein and organelle degradation, which is likely to represent an innate adaptation to starvation. In times of nutrient deficiency...
NuMA is required for proper spindle assembly and chromosome alignment in prometaphase
Journal Article
Haren, L., Gnadt, N., Wright, M., & Merdes, A. (2009)
NuMA is required for proper spindle assembly and chromosome alignment in prometaphase. BMC Research Notes, 2, 1-6. https://doi.org/10.1186/1756-0500-2-64
NuMA is a protein that has been previously shown to play a role in focusing microtubules at the mitotic spindle poles. However, most previous work relies on experimental metho...
Senescent T-lymphocytes are mobilised into the peripheral blood compartment in young and older humans after exhaustive exercise
Journal Article
Simpson, R. J., Cosgrove, C., Ingram, L. A., Florida-James, G. D., Whyte, G. P., Pircher, H., & Guy, K. (2008)
Senescent T-lymphocytes are mobilised into the peripheral blood compartment in young and older humans after exhaustive exercise. Brain, Behavior, and Immunity, 22(4), 544-551. https://doi.org/10.1016/j.bbi.2007.11.002
Senescent T-lymphocytes are antigen-experienced cells that express the killer-cell lectin-like receptor G1 (KLRG1) and/or CD57; fail to clonally expand following further antig...
Parasitic helminths tip the balance: potential anti-inflammatory therapies
Journal Article
Proudfoot, L. (2004)
Parasitic helminths tip the balance: potential anti-inflammatory therapies. Immunology, 113(4), 438-440. https://doi.org/10.1111/j.1365-2567.2004.01996.x
Parasitic helminths are worms that are classified within the phyla Nematoda (roundworms) and Platyhelminthes (flatworms) (see Table 1). Some nematode species, Filariae being a...