Herd-level prevalence of selected endemic infectious diseases of dairy cows in Great Britain
Journal Article
Velasova, M., Damaso, A., Prakashbabu, B. C., Gibbons, J., Wheelhouse, N., Longbottom, D., …Guitian, J. (2017)
Herd-level prevalence of selected endemic infectious diseases of dairy cows in Great Britain. Journal of Dairy Science, 100(11), 9215-9233. https://doi.org/10.3168/jds.2016-11863
To implement appropriate and effective disease control programs at national level, up-to-date and unbiased information on disease frequency is needed. The aim of this study w...
Pathogenic outcome following experimental infection of sheep with Chlamydia abortus variant strains LLG and POS
Journal Article
Livingstone, M., Wheelhouse, N., Ensor, H., Rocchi, M., Maley, S., Aitchison, K., …Longbottom, D. (2017)
Pathogenic outcome following experimental infection of sheep with Chlamydia abortus variant strains LLG and POS. PLOS ONE, 12(5), https://doi.org/10.1371/journal.pone.0177653
This study investigated the pathogenesis of two variant strains (LLG and POS) of Chlamydia abortus, in comparison to a typical wild-type strain (S26/3) which is known to be re...
Ovine trophoblasts express cathelicidin host defence peptide in response to infection
Journal Article
Coyle, C., Wheelhouse, N., Jacques, M., Longbottom, D., Svoboda, P., Pohl, J., …Barlow, P. G. (2016)
Ovine trophoblasts express cathelicidin host defence peptide in response to infection. Journal of Reproductive Immunology, 117, 10-16. https://doi.org/10.1016/j.jri.2016.06.006
Cationic host defence peptides (CHDP; also known as antimicrobial peptides) are key components of the immune response in the female reproductive tract. The role of the placent...
Waddlia chondrophila Infects and Multiplies in Ovine Trophoblast Cells Stimulating an Inflammatory Immune Response
Journal Article
Wheelhouse, N., Coyle, C., Barlow, P. G., Mitchell, S., Greub, G., Baszler, T., …Longbottom, D. (2014)
Waddlia chondrophila Infects and Multiplies in Ovine Trophoblast Cells Stimulating an Inflammatory Immune Response. PLOS ONE, 9(7), https://doi.org/10.1371/journal.pone.0102386
BACKGROUND
Waddlia chondrophila (W. chondrophila) is an emerging abortifacient organism which has been identified in the placentae of humans and cattle. The organism is a mem...
Absence of correlation between serum CRP levels and mitochondrial D-loop DNA mutations in gastro-oesophageal adenocarcinoma
Journal Article
Tan, B. H. L., Skipworth, R. J. E., Wheelhouse, N. M., Fearon, K. C. H., & Ross, J. A. (2014)
Absence of correlation between serum CRP levels and mitochondrial D-loop DNA mutations in gastro-oesophageal adenocarcinoma. Journal of Cancer Research and Therapeutics, 10(1), 176-9. https://doi.org/10.4103/0973-1482.131458
INTRODUCTION: Both inflammation and mitochondrial DNA (mtDNA) mutation are thought to play a role in the many human cancers. The aim of this study was to evaluate the relation...
Genome sequencing and comparative analysis of three Chlamydia pecorum strains associated with different pathogenic outcomes
Journal Article
Sait, M., Livingstone, M., Clark, E. M., Wheelhouse, N., Spalding, L., Markey, B., …Longbottom, D. (2014)
Genome sequencing and comparative analysis of three Chlamydia pecorum strains associated with different pathogenic outcomes. BMC Genomics, 15, 23. https://doi.org/10.1186/1471-2164-15-23
BACKGROUND: Chlamydia pecorum is the causative agent of a number of acute diseases, but most often causes persistent, subclinical infection in ruminants, swine and birds. In t...
Genome sequence of the Chlamydophila abortus variant strain LLG
Journal Article
Sait, M., Clark, E. M., Wheelhouse, N., Livingstone, M., Spalding, L., Siarkou, V. I., …Longbottom, D. (2011)
Genome sequence of the Chlamydophila abortus variant strain LLG. Journal of Bacteriology, 193(16), 4276-4277. https://doi.org/10.1128/JB.05290-11
Chlamydophila abortus is a common cause of ruminant abortion. Here we report the genome sequence of strain LLG, which differs genotypically and phenotypically from the wild-ty...