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The Ex Vivo Organ Culture of Bone

Book Chapter
Staines, K. A., Brown, G., & Farquharson, C. (2019)
The Ex Vivo Organ Culture of Bone. In Bone Research Protocols (199-215). New york, USA: Humana Press. https://doi.org/10.1007/978-1-4939-8997-3_10
The ex vivo organ culture of bone provides many of the advantages of both the whole organism and isolated cell strategies and can deliver valuable insight into the network of ...

Regulation and Function of the Original p53- Inducible p21 Gene

Book Chapter
Fraser, J. A. (2010)
Regulation and Function of the Original p53- Inducible p21 Gene. In p53; Molecular Biology Intelligence Unit, 100-116. Springer Science + Business Media. https://doi.org/10.1007/978-1-4419-8231-5_7
P21 is a well known regulator of cell cycle progression through its inhibitory actions on Cyclin dependent kinases, (Cdk)/cyclin complexes, and DNA replication via its binding...

GABA-, Glycine-, and Glutamate-Gated Channels and Their Possible Involvement in Neurological and Psychiatric Illness

Book Chapter
Darlison, M. G., & Harvey, R. J. (1996)
GABA-, Glycine-, and Glutamate-Gated Channels and Their Possible Involvement in Neurological and Psychiatric Illness. In Molecular Biology of Membrane Transport Disorders, 169-180. Springer Verlag. https://doi.org/10.1007/978-1-4613-1143-0_9
Rapid chemical communication between cells in the vertebrate central nervous system is mediated by ligand-gated ion-channel receptors (also called ionotropic receptors), which...

The Structure and Expression of the GABAA Receptor as Deduced by Molecular Genetic Studies

Book Chapter
Darlison, M. G., Barnard, E. A., Bateson, A. N., Glencorse, T. A., Harvey, R. J., Hicks, A. A., …Wisden, W. (1989)
The Structure and Expression of the GABAA Receptor as Deduced by Molecular Genetic Studies. In Molecular Biology of Neuroreceptors and Ion Channels, 83-99. Springer Verlag. https://doi.org/10.1007/978-3-642-74155-5_7
It is well established that the inhibitory neurotransmitter γ-aminobutyric acid (GABA) mediates many of its effects by binding to the GABAA receptor, which is present on the m...

Molecular Biology of Nicotinic Acetylcholine Receptors from Chicken Muscle and Brain

Book Chapter
Squire, M. D., Moss, S. J., Lai, F. A., Darlison, M. G., Cockcroft, V. B., Barnard, E. A., …Ross, S. J. (1986)
Molecular Biology of Nicotinic Acetylcholine Receptors from Chicken Muscle and Brain. In A. Maelicke (Ed.), Nicotinic Acetylcholine Receptor, 389-415. Springer Verlag. https://doi.org/10.1007/978-3-642-71649-2_30
While it has been completely established that the AChR** as isolated from the electroplaques of electric fish is composed of four different polypeptides, such that its subunit...