Monocyte chemoattractant protein-induced protein 1 impairs adipogenesis in 3T3-L1 cells
Journal Article
Lipert, B., Wegrzyn, P., Sell, H., Eckel, J., Winiarski, M., Budzynski, A., …Jura, J. (2014)
Monocyte chemoattractant protein-induced protein 1 impairs adipogenesis in 3T3-L1 cells. BBA - Molecular Cell Research, 1843(4), 780-788. https://doi.org/10.1016/j.bbamcr.2014.01.001
Monocyte chemoattractant protein-induced protein 1 (MCPIP1) encoded by the ZC3H12a gene (also known as Regnase-1) is involved in the regulation of degradation of mRNA of infla...
The BioGRID interaction database: 2013 update
Journal Article
Chatr-aryamontri, A., Breitkreutz, B., Heinicke, S., Boucher, L., Winter, A., Stark, C., …Tyers, M. (2013)
The BioGRID interaction database: 2013 update. Nucleic Acids Research, 41(D1), D816-D823. https://doi.org/10.1093/nar/gks1158
The Biological General Repository for Interaction Datasets (BioGRID: http//thebiogrid.org) is an open access archive of genetic and protein interactions that are curated from ...
Regulation and Function of the Original p53- Inducible p21 Gene
Book Chapter
Fraser, J. A. (2010)
Regulation and Function of the Original p53- Inducible p21 Gene. In p53; Molecular Biology Intelligence Unit, 100-116. Springer Science + Business Media. https://doi.org/10.1007/978-1-4419-8231-5_7
P21 is a well known regulator of cell cycle progression through its inhibitory actions on Cyclin dependent kinases, (Cdk)/cyclin complexes, and DNA replication via its binding...
Quinol-cytochrome c Oxidoreductase and Cytochrome c4 Mediate Electron Transfer during Selenate Respiration in Thauera selenatis
Journal Article
Lowe, E. C., Bydder, S., Hartshorne, R. S., Tape, H. L. U., Dridge, E. J., Debieux, C. M., …Butler, C. S. (2010)
Quinol-cytochrome c Oxidoreductase and Cytochrome c4 Mediate Electron Transfer during Selenate Respiration in Thauera selenatis. Journal of Biological Chemistry, 285(24), 18433-18442. https://doi.org/10.1074/jbc.M110.115873
Selenate reductase (SER) from Thauera selenatis is a periplasmic enzyme that has been classified as a type II molybdoenzyme. The enzyme comprises three subunits SerABC, where ...
P088 Involvement of NMDAR in chondrocyte cell death and matrix degeneration
Presentation / Conference
Ramage, L., Hardingham, G. & Salter, D. (2009, June)
P088 Involvement of NMDAR in chondrocyte cell death and matrix degeneration. Paper presented at 2nd Joint meeting of the Bone Research Society and the British Society for Matrix Biology, London
NMDA receptors (NMDAR) are expressed by chondrocytes in
articular cartilage although their function is yet to be fully
understood. NMDAR are ionotropic glutamate receptors whi...
Signalling cascades in mechanotransduction: cell-matrix interactions and mechanical loading
Journal Article
Ramage, L., Nuki, G., & Salter, D. M. (2009)
Signalling cascades in mechanotransduction: cell-matrix interactions and mechanical loading. Scandinavian Journal of Medicine and Science in Sports, 19(4), 457-469. https://doi.org/10.1111/j.1600-0838.2009.00912.x
Mechanical loading of articular cartilage stimulates the metabolism of resident chondrocytes and induces the synthesis of molecules to maintain the integrity of the cartilage....
NuMA is required for proper spindle assembly and chromosome alignment in prometaphase
Journal Article
Haren, L., Gnadt, N., Wright, M., & Merdes, A. (2009)
NuMA is required for proper spindle assembly and chromosome alignment in prometaphase. BMC Research Notes, 2, 1-6. https://doi.org/10.1186/1756-0500-2-64
NuMA is a protein that has been previously shown to play a role in focusing microtubules at the mitotic spindle poles. However, most previous work relies on experimental metho...
The alternative splice variant of DAPK-1, s-DAPK-1, induces proteasome-independent DAPK-1 destabilization.
Journal Article
Lin, Y., Stevens, C., Harrison, B., Pathuri, S., Amin, E., & Hupp, T. R. (2009)
The alternative splice variant of DAPK-1, s-DAPK-1, induces proteasome-independent DAPK-1 destabilization. Molecular and Cellular Biochemistry, 328(1-2), (101-107). doi:10.1007/s11010-009-0079-4. ISSN 0300-8177
Death-associated protein kinase 1 (DAPK-1) is a Ca2+/CaM-regulated kinase involved in multiple cellular signalling pathways that trigger cell survival, apoptosis, and autophag...
DAPK-1 Bbnding to a linear peptide motif in MAP1B stimulates autophagy and membrane blebbing
Journal Article
Harrison, B., Kraus, M., Burch, L., Stevens, C., Craig, A., Gordon-Weeks, P., & Hupp, T. R. (2008)
DAPK-1 Bbnding to a linear peptide motif in MAP1B stimulates autophagy and membrane blebbing. Journal of Biological Chemistry, 283(15), 9999-10014. https://doi.org/10.1074/jbc.M706040200
DAPK-1 (death-activated protein kinase) has wide ranging functions in cell growth control; however, DAPK-1 interacting proteins that mediate these effects are not well defined...
The MDM2 Ubiquitination Signal in the DNA-Binding Domain of p53 Forms a Docking Site for Calcium Calmodulin Kinase Superfamily Members
Journal Article
Craig, A. L., Chrystal, J. A., Fraser, J. A., Sphyris, N., Lin, Y., Harrison, B. J., …Hupp, T. R. (2007)
The MDM2 Ubiquitination Signal in the DNA-Binding Domain of p53 Forms a Docking Site for Calcium Calmodulin Kinase Superfamily Members. Molecular and Cellular Biology, 27(9), 3542-3555. https://doi.org/10.1128/mcb.01595-06
Genetic and biochemical studies have shown that Ser20 phosphorylation in the transactivation domain of p53 mediates p300-catalyzed DNA-dependent p53 acetylation and B-cell tum...