How to build a bone: PHOSPHO1, biomineralization and beyond
Journal Article
Dillon, S., Staines, K. A., Millán, J. L., & Farquharson, C. (2019)
How to build a bone: PHOSPHO1, biomineralization and beyond. Journal of Bone and Mineral Research Plus, 3(7), https://doi.org/10.1002/jbm4.10202
Since its characterization two decades ago, the phosphatase PHOSPHO1 has been the subject of an increasing focus of research. This work has elucidated PHOSPHO1’s central role ...
The Ex Vivo Organ Culture of Bone
Book Chapter
Staines, K. A., Brown, G., & Farquharson, C. (2019)
The Ex Vivo Organ Culture of Bone. In Bone Research Protocols (199-215). New york, USA: Humana Press. https://doi.org/10.1007/978-1-4939-8997-3_10
The ex vivo organ culture of bone provides many of the advantages of both the whole organism and isolated cell strategies and can deliver valuable insight into the network of ...
Silver nanoparticles promote the emergence of heterogeneic human neutrophil sub-populations
Journal Article
Kemp, S., Young, L., Ross, M., Prach, M., Hutchison, G. R., Malone, E., & Fraser, J. A. (2018)
Silver nanoparticles promote the emergence of heterogeneic human neutrophil sub-populations. Scientific Reports, 8(1), https://doi.org/10.1038/s41598-018-25854-2
Neutrophil surveillance is central to nanoparticle clearance. Silver nanoparticles (AgNP) have numerous uses, however conflicting evidence exists as to their impact on neutrop...
Relative age effects in international age group championships: A study of Spanish track and field athletes
Journal Article
Brazo-Sayavera, J., Martínez-Valencia, M. A., Müller, L., Andronikos, G., & Martindale, R. J. J. (2018)
Relative age effects in international age group championships: A study of Spanish track and field athletes. PLOS ONE, 13(4), https://doi.org/10.1371/journal.pone.0196386
The relative age effect is a well-researched phenomenon, however there is still a dearth of understanding in track and field and female sport. This study investigated the role...
Overexpression of TIMP-3 in Chondrocytes Produces Transient Reduction in Growth Plate Length but Permanently Reduces Adult Bone Quality and Quantity
Journal Article
Poulet, B., Liu, K., Plumb, D., Vo, P., Shah, M., Staines, K., …Bou-Gharios, G. (2016)
Overexpression of TIMP-3 in Chondrocytes Produces Transient Reduction in Growth Plate Length but Permanently Reduces Adult Bone Quality and Quantity. PLOS ONE, 11(12), https://doi.org/10.1371/journal.pone.0167971
Bone development and length relies on the growth plate formation, which is dependent on degradative enzymes such as MMPs. Indeed, deletion of specific members of this enzyme f...
Increased Glucose Transport into Neurons Rescues Aβ Toxicity in Drosophila
Journal Article
Niccoli, T., Cabecinha, M., Tillmann, A., Kerr, F., Wong, C., Cardenes, D., …Partridge, L. (2016)
Increased Glucose Transport into Neurons Rescues Aβ Toxicity in Drosophila. Current Biology, 26(17), 2291-2300. https://doi.org/10.1016/j.cub.2016.07.017
Glucose hypometabolism is a prominent feature of the brains of patients with Alzheimer's disease (AD). Disease progression is associated with a reduction in glucose transporte...
PP2ACdc55’s role in reductional chromosome segregation during achiasmate meiosis in budding yeast is independent of its FEAR function
Journal Article
Kerr, G. W., Wong, J. H., & Arumugam, P. (2016)
PP2ACdc55’s role in reductional chromosome segregation during achiasmate meiosis in budding yeast is independent of its FEAR function. Scientific Reports, 6(1), https://doi.org/10.1038/srep30397
PP2ACdc55 is a highly conserved serine-threonine protein phosphatase that is involved in diverse cellular processes. In budding yeast, meiotic cells lacking PP2ACdc55 activity...
Cationic host defense peptides; novel antimicrobial therapeutics against Category A pathogens and emerging infections
Journal Article
Findlay, F., Proudfoot, L., Stevens, C., & Barlow, P. G. (2016)
Cationic host defense peptides; novel antimicrobial therapeutics against Category A pathogens and emerging infections. Pathogens and Global Health, 110(4-5), 137-147. https://doi.org/10.1080/20477724.2016.1195036
Cationic Host Defense Peptides (HDP, also known as antimicrobial peptides) are crucial components of the innate immune system and possess broad-spectrum antibacterial, antivir...
BioGRID: A Resource for Studying Biological Interactions in Yeast: Table 1.
Journal Article
Oughtred, R., Chatr-aryamontri, A., Breitkreutz, B., Chang, C. S., Rust, J. M., Theesfeld, C. L., …Tyers, M. (2016)
BioGRID: A Resource for Studying Biological Interactions in Yeast: Table 1. Cold Spring Harbor protocols, 2016(1), pdb.top080754. https://doi.org/10.1101/pdb.top080754
The Biological General Repository for Interaction Datasets (BioGRID) is a freely available public database that provides the biological and biomedical research communities wit...
The BioGRID interaction database: 2015 update
Journal Article
Chatr-aryamontri, A., Breitkreutz, B., Oughtred, R., Boucher, L., Heinicke, S., Chen, D., …Tyers, M. (2015)
The BioGRID interaction database: 2015 update. Nucleic Acids Research, 43(D1), D470-D478. https://doi.org/10.1093/nar/gku1204
The Biological General Repository for Interaction Datasets (BioGRID: http://thebiogrid.org) is an open access database that houses genetic and protein interactions curated fro...