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200 results

Urinary specific gravity as an alternative for the normalisation of endocrine metabolite concentrations in giant panda (Ailuropoda melanoleuca) reproductive monitoring

Journal Article
Wauters, J., Wilson, K. S., Bouts, T., Valentine, I., Vanderschueren, K., Ververs, C., …Vanhaecke, L. (2018)
Urinary specific gravity as an alternative for the normalisation of endocrine metabolite concentrations in giant panda (Ailuropoda melanoleuca) reproductive monitoring. PLOS ONE, 13(7), https://doi.org/10.1371/journal.pone.0201420
Reproductive monitoring for captive breeding in giant pandas is based on behavioural observation and non-invasive hormone analysis. In urine, interpretation of results require...

Beware Biofilm! Dry biofilms containing bacterial pathogens on multiple healthcare surfaces; a multicentre study

Journal Article
Ledwoch, K., Dancer, S., Otter, J., Kerr, K., Roposte, D., Rushton, L., …Maillard, J. (2018)
Beware Biofilm! Dry biofilms containing bacterial pathogens on multiple healthcare surfaces; a multicentre study. Journal of Hospital Infection, doi:10.1016/j.jhin.2018.06.028
Background Wet biofilms associated with medical devices have been widely studied and their link with healthcare-associated infections (HCAIs) is well recognized. Little attent...

Older men display elevated levels of senescence-associated exercise-responsive CD28null angiogenic T cells compared with younger men

Journal Article
Ross, M., Ingram, L., Taylor, G., Malone, E., Simpson, R. J., West, D., & Florida-James, G. (2018)
Older men display elevated levels of senescence-associated exercise-responsive CD28null angiogenic T cells compared with younger men. Physiological Reports, 6(12), 1-11. https://doi.org/10.14814/phy2.13697
Aging is associated with elevated cardiovascular disease risk. As a result of aging, endothelial dysfunction develops, partly due to a reduction in vascular regenerative abili...

Antiviral therapeutic approaches for human rhinovirus infections

Journal Article
Casanova, V., Sousa, F. H., Stevens, C., & Barlow, P. G. (2018)
Antiviral therapeutic approaches for human rhinovirus infections. Future Virology, https://doi.org/10.2217/fvl-2018-0016
Human rhinoviruses (RV) are the primary etiological agent of the common cold. This infection can be mild and self-limiting in immunocompetent hosts, but can be associated wit...

Silver nanoparticles promote the emergence of heterogeneic human neutrophil sub-populations

Journal Article
Kemp, S., Young, L., Ross, M., Prach, M., Hutchison, G. R., Malone, E., & Fraser, J. A. (2018)
Silver nanoparticles promote the emergence of heterogeneic human neutrophil sub-populations. Scientific Reports, 8(1), https://doi.org/10.1038/s41598-018-25854-2
Neutrophil surveillance is central to nanoparticle clearance. Silver nanoparticles (AgNP) have numerous uses, however conflicting evidence exists as to their impact on neutrop...

Diurnal Variation in Physiological and Immune Responses to Endurance Sport in Highly Trained Runners in a Hot and Humid Environment

Journal Article
Boukelia, Z., Gomes, E. C., & Florida-James, G. D. (2018)
Diurnal Variation in Physiological and Immune Responses to Endurance Sport in Highly Trained Runners in a Hot and Humid Environment. Oxidative Medicine and Cellular Longevity, 2018, https://doi.org/10.1155/2018/3402143
Purpose. The purpose of this study was to investigate the physiological and immunological response of highly trained runners to an intense bout of exercise performed at two di...

Is there an association between airborne and surface microbes in the critical care environment?

Journal Article
Smith, J., Adams, C., King, M., Noakes, C., Robertson, C., & Dancer, S. (2018)
Is there an association between airborne and surface microbes in the critical care environment?. Journal of Hospital Infection, https://doi.org/10.1016/j.jhin.2018.04.003
Background There are few data and no accepted standards for air quality in the intensive care unit (ICU). Any relationship between airborne pathogens and hospital-acquired inf...

Quantifying the relative effect of environmental contamination on surgical ward MRSA incidence: An exploratory analysis

Journal Article
Lee, X. J., Pettitt, A. N., & Dancer, S. J. (2018)
Quantifying the relative effect of environmental contamination on surgical ward MRSA incidence: An exploratory analysis. Infection, Disease & Health, https://doi.org/10.1016/j.idh.2018.02.005
Background: To investigate and quantify the contribution of environmental contamination towards methicillin-resistant Staphylococcus aureus (MRSA) incidence observed in a hosp...

Pelvic Chlamydial Infection Predisposes to Ectopic Pregnancy by Upregulating Integrin β1 to Promote Embryo-tubal Attachment

Journal Article
Ahmad, S. F., Brown, J. K., Campbell, L. L., Koscielniak, M., Oliver, C., Wheelhouse, N., …Horne, A. W. (2018)
Pelvic Chlamydial Infection Predisposes to Ectopic Pregnancy by Upregulating Integrin β1 to Promote Embryo-tubal Attachment. EBioMedicine, 29, 159-165. https://doi.org/10.1016/j.ebiom.2018.02.020
Tubal ectopic pregnancies are a leading cause of global maternal morbidity and mortality. Previous infection with Chlamydia trachomatis is a major risk factor for tubal embryo...

How Does a Photocatalytic Antimicrobial Coating Affect Environmental Bioburden in Hospitals?

Journal Article
Reid, M., Whatley, V., Spooner, E., Nevill, A. M., Cooper, M., Ramsden, J. J., & Dancer, S. J. (2018)
How Does a Photocatalytic Antimicrobial Coating Affect Environmental Bioburden in Hospitals?. Infection Control and Hospital Epidemiology, 39(4), 398-404. https://doi.org/10.1017/ice.2017.297
BACKGROUND The healthcare environment is recognized as a source for healthcare-acquired infection. Because cleaning practices are often erratic and always intermittent, we hyp...
33 results

Medical Research Scotland Vacation Scholarship

2022 - 2023
Investigating the anti-metastatic potential of Honokiol by attenuating KISS1/ KISS1R signaling
Funder: Medical Research Scotland | Value: £2,160

Exploiting micofluidic devices for physiologically relavent drug screening against human pathogens

2022 - 2022
Undergraduate student summer project (8 weeks)
Funder: Medical Research Scotland | Value: £2,160

Enhancing the stability and the delivery of lactoferrin for prevention and/or treatment of covid-19 respiratory disease.

2022 - 2023
Lactoferrin (LF) is a glycoprotein which is widely contained in many secretory fluids, mainly milk but also saliva, tears, and nasal secretions. Many scientific reports supported an application of thi...
Funder: Royal Society | Value: £17,494

Do iron-oxide nanoparticles contribute to Parkinsons Disease pathology?

2021 - 2022
Anthropogenic iron-oxide nanoparticles (IONPs) detected in ultrafine particulate matter caused by traffic and industrial emissions have increased substantially over time, constituting one of the most ...
Funder: RS Macdonald Charitable Trust | Value: £1,500

Covid-19 support scheme for Postdoctoral researchers 2021

2021 - 2021
Covid-19 support scheme for Postdoctoral researchers 2021
Funder: Society for Reproduction and Fertility | Value: £12,386

Developing an adoptive regulatory T cell therapy for the treatment of rheumatoid arthritis

2021 - 2024
The immune system contains a balance of cells that turn responses ‘on’ and those that turn it ‘off’. When this balance breaks down, inappropriate immune responses can attack healthy tissue...
Funder: Chief Scientists Office | Value: £229,020

Uncovering novel effectors of Nrf2 dysregulation in the progression of Alzheimer's Disease

2020 - 2021
Nrf2 activators show pre-clinical promise in the treatment of several neurodegenerative diseases, including Alzheimer’s disease (AD), but exert clinical toxicity. Nrf2 regulates hundreds of anti-oxida...
Funder: Alzheimer's Research UK | Value: £4,219

Host Defence Peptides as novel modulators of autophagy in Inflammatory Bowel Disease

2019 - 2022
Increasing numbers of patients are diagnosed with inflammatory bowel disease (IBD) each year, both in the United Kingdom and worldwide. Most drugs in current use for the treatment of IBD target the im...
Funder: The Daphne Jackson Trust | Value: £83,167

EEID travel award: Understanding transmission dynamics for bacterial zoonoses in humans, goats and camels among pastoral communities in Northern Kenya

2019 - 2019
EEID travel award: Understanding transmission dynamics for bacterial zoonoses in humans, goats and camels among pastoral communities in Northern Kenya
Funder: Biotechnology and Biological Sciences Research Council | Value: £1,960

Can exposure to excess androgen during fetal life increase risk of hepatic disease in male offspring?

2019 - 2019
Background Polycystic ovary syndrome (PCOS) is a common condition. Hyperandrogenaemia characterises PCOS, and is considered an ‘in utero environmental programmer’ of PCOS in female offspring. Male o...
Funder: Society for Reproduction and Fertility | Value: £3,000