The Expression of PHOSPHO1, nSMase2 and TNAP is Coordinately Regulated by Continuous PTH Exposure in Mineralising Osteoblast Cultures
Journal Article
Houston, D. A., Myers, K., MacRae, V. E., Staines, K. A., & Farquharson, C. (2016)
The Expression of PHOSPHO1, nSMase2 and TNAP is Coordinately Regulated by Continuous PTH Exposure in Mineralising Osteoblast Cultures. Calcified Tissue International, 99(5), 510-524. https://doi.org/10.1007/s00223-016-0176-9
Sustained exposure to high levels of parathyroid hormone (PTH), as observed in hyperparathyroidism, are catabolic to bone. The increase in the RANKL/OPG ratio in response to c...
Effects of etidronate on the Enpp1−/− mouse model of generalized arterial calcification of infancy
Journal Article
Huesa, C., Staines, K. A., Millán, J. L., & MacRae, V. E. (2015)
Effects of etidronate on the Enpp1−/− mouse model of generalized arterial calcification of infancy. International Journal of Molecular Medicine, 36(1), 159-165. https://doi.org/10.3892/ijmm.2015.2212
Generalized arterial calcification of infancy (GACI) is an autosomal recessive disorder of spontaneous infantile arterial and periarticular calcification which is attributed t...
Identification of novel regulators of osteoblast matrix mineralization by time series transcriptional profiling
Journal Article
Staines, K. A., Zhu, D., Farquharson, C., & MacRae, V. E. (2014)
Identification of novel regulators of osteoblast matrix mineralization by time series transcriptional profiling. Journal of Bone and Mineral Metabolism, 32(3), 240-251. https://doi.org/10.1007/s00774-013-0493-2
Bone mineralization is a carefully orchestrated process, regulated by a number of promoters and inhibitors that function to ensure effective hydroxyapatite formation. Here we ...
Chondrogenic ATDC5 cells: An optimised model for rapid and physiological matrix mineralisation
Journal Article
Newton, P. T., Staines, K. .. . A., Spevak, L., Boskey, A. L., Teixeira, C. C., Macrae, V. E., …Farquharson, C. (2012)
Chondrogenic ATDC5 cells: An optimised model for rapid and physiological matrix mineralisation. International Journal of Molecular Medicine, 30(5), 1187-1193. https://doi.org/10.3892/ijmm.2012.1114
The development of chondrogenic cell lines has led to major advances in the understanding of how chondrocyte differentiation is regulated, and has uncovered many signalling pa...
MEPE is a novel regulator of growth plate cartilage mineralization
Journal Article
Staines, K. A., Mackenzie, N. C. W., Clarkin, C. E., Zelenchuk, L., Rowe, P. S., MacRae, V. E., & Farquharson, C. (2012)
MEPE is a novel regulator of growth plate cartilage mineralization. Bone, 51(3), 418-430. https://doi.org/10.1016/j.bone.2012.06.022
Matrix extracellular phosphoglycoprotein (MEPE) belongs to the SIBLING protein family which play key roles in biomineralization. Although the growth plates of MEPE-overexpress...
The skeleton: no bones about it
Journal Article
Farquharson, C., & Staines, K. (2011)
The skeleton: no bones about it. Journal of Endocrinology, 211(2), 107-108. doi:10.1530/joe-11-0274
NO abstract available.