The type III intermediate filament vimentin regulates organelle distribution and modulates autophagy
Journal Article
Biskou, O., Casanova, V., Hooper, K., Kemp, S., Wright, G. P., Satsangi, J., …Stevens, C. (2019)
The type III intermediate filament vimentin regulates organelle distribution and modulates autophagy. PLOS ONE, 14(1), https://doi.org/10.1371/journal.pone.0209665
The cytoskeletal protein vimentin plays a key role in positioning of organelles within the cytosol and has been linked to the regulation of numerous cellular processes includi...
Belonging to a learning community: staff perspectives.
Presentation / Conference
Ennis, L., Tierney, A., Lucas, L., Logan, P., & Wright, G. (2018, October)
Belonging to a learning community: staff perspectives. Presented at Evidence for Enhancement: The Challenge of Community and Belonging
The Faculty Learning Community (FLC) at Edinburgh Napier University is based on the Miami model developed by Milton D. Cox and seeks to explore the ways in which staff support...
Lower Resting and Exercise-Induced Circulating Angiogenic Progenitors and Angiogenic T-Cells in Older Men
Journal Article
Ross, M. D., Malone, E. M., Simpson, R., Cranston, I., Ingram, L., Wright, G. P., …Florida-James, G. D. (2018)
Lower Resting and Exercise-Induced Circulating Angiogenic Progenitors and Angiogenic T-Cells in Older Men. American journal of physiology. Heart and circulatory physiology, 314(3), 392-402. https://doi.org/10.1152/ajpheart.00592.2017
Ageing is associated with a dysfunctional endothelial phenotype, as well as reduced angiogenic capabilities. Exercise exerts beneficial effects on the cardiovascular system, p...
Remote ischaemic preconditioning in orthotopic liver transplantation (RIPCOLT trial): a pilot randomized controlled feasibility study
Journal Article
Robertson, F. P., Goswami, R., Wright, G. P., Imber, C., Sharma, D., Malago, M., …Davidson, B. R. (2017)
Remote ischaemic preconditioning in orthotopic liver transplantation (RIPCOLT trial): a pilot randomized controlled feasibility study. HPB, 19(9), 757-767. https://doi.org/10.1016/j.hpb.2017.05.005
Background
Ischaemia Reperfusion (IR) injury is a major cause of morbidity, mortality and graft loss following Orthotopic Liver Transplantation (OLT). Utilising marginal graft...
CD3 limits the efficacy of TCR gene therapy in vivo
Journal Article
Ahmadi, M., King, J. W., Xue, S. A., Voisine, C., Holler, A., Wright, G. P., …Stauss, H. J. (2011)
CD3 limits the efficacy of TCR gene therapy in vivo. Blood, 118(13), 3528-3537. https://doi.org/10.1182/blood-2011-04-346338
The function of T-cell receptor (TCR) gene modified T cells is dependent on efficient surface expression of the introduced TCR / heterodimer. We tested whether endogenous CD3...
Therapeutic potential of Tregs to treat rheumatoid arthritis
Journal Article
Wright, G. P., Stauss, H. J., & Ehrenstein, M. R. (2011)
Therapeutic potential of Tregs to treat rheumatoid arthritis. Seminars in Immunology, 23(3), 195-201. https://doi.org/10.1016/j.smim.2011.07.004
There is accumulating evidence for regulatory T cell defects in rheumatoid arthritis and that some biologic interventions, in particular anti-TNF, can target this population. ...
Clinical Applications of Autoimmunity to Citrullinated Proteins in Rheumatoid Arthritis, from Improving Diagnostics to Future Therapies
Journal Article
Kinloch, A. J., Ng, K., & Wright, G. P. (2011)
Clinical Applications of Autoimmunity to Citrullinated Proteins in Rheumatoid Arthritis, from Improving Diagnostics to Future Therapies. Recent patents on inflammation & allergy drug discovery, 5(2), 108-127. https://doi.org/10.2174/187221311795399246
Rheumatoid arthritis (RA), although widely considered to be the most commonly occurring autoimmune disease, has only truly been substantiated as a distinct autoimmune disease ...
Natural IgM Is Required for Suppression of Inflammatory Arthritis by Apoptotic Cells
Journal Article
Notley, C. A., Brown, M. A., Wright, G. P., & Ehrenstein, M. R. (2011)
Natural IgM Is Required for Suppression of Inflammatory Arthritis by Apoptotic Cells. The journal of immunology : official journal of the American Association of Immunologists, 186(8), 4967-4972. https://doi.org/10.4049/jimmunol.1003021
The clearance of dying cells is vital for re-establishing tolerance during inflammation and has potent immunoregulatory consequences. Because natural IgM plays a key role in t...
Adoptive therapy with redirected primary regulatory T cells results in antigen-specific suppression of arthritis
Journal Article
Wright, G. P., Notley, C. A., Xue, S. A., Bendle, G. M., Holler, A., Schumacher, T. N., …Stauss, H. J. (2009)
Adoptive therapy with redirected primary regulatory T cells results in antigen-specific suppression of arthritis. Proceedings of the National Academy of Sciences, 106(45), 19078-19083. https://doi.org/10.1073/pnas.0907396106
Regulatory T cells (Tregs) can suppress a wide range of immune cells, making them an ideal candidate for the treatment of autoimmunity. The potential clinical translation of t...