Direct Keap1-Nrf2 disruption as a potential therapeutic target for Alzheimer’s disease
Journal Article
Kerr, F., Sofola-Adesakin, O., Ivanov, D. K., Gatliff, J., Gomez Perez-Nievas, B., Bertrand, H. C., …Partridge, L. (2017)
Direct Keap1-Nrf2 disruption as a potential therapeutic target for Alzheimer’s disease. PLoS Genetics, 13(3), https://doi.org/10.1371/journal.pgen.1006593
Nrf2, a transcriptional activator of cell protection genes, is an attractive therapeutic target for the prevention of neurodegenerative diseases, including Alzheimer’s disease...
Increased Glucose Transport into Neurons Rescues Aβ Toxicity in Drosophila
Journal Article
Niccoli, T., Cabecinha, M., Tillmann, A., Kerr, F., Wong, C., Cardenes, D., …Partridge, L. (2016)
Increased Glucose Transport into Neurons Rescues Aβ Toxicity in Drosophila. Current Biology, 26(17), 2291-2300. https://doi.org/10.1016/j.cub.2016.07.017
Glucose hypometabolism is a prominent feature of the brains of patients with Alzheimer's disease (AD). Disease progression is associated with a reduction in glucose transporte...
Inhibition of GSK-3 Ameliorates Aβ Pathology in an Adult-Onset Drosophila Model of Alzheimer's Disease
Journal Article
Sofola, O., Kerr, F., Rogers, I., Killick, R., Augustin, H., Gandy, C., …Partridge, L. (2010)
Inhibition of GSK-3 Ameliorates Aβ Pathology in an Adult-Onset Drosophila Model of Alzheimer's Disease. PLoS Genetics, 6(9), https://doi.org/10.1371/journal.pgen.1001087
Aβ peptide accumulation is thought to be the primary event in the pathogenesis of Alzheimer's disease (AD), with downstream neurotoxic effects including the hyperphosphorylati...
Dietary restriction delays aging, but not neuronal dysfunction, in Drosophila models of Alzheimer's disease
Journal Article
Kerr, F., Augustin, H., Piper, M. D. W., Gandy, C., Allen, M. J., Lovestone, S., & Partridge, L. (2011)
Dietary restriction delays aging, but not neuronal dysfunction, in Drosophila models of Alzheimer's disease. Neurobiology of Aging, 32(11), 1977-1989. https://doi.org/10.1016/j.neurobiolaging.2009.10.015
Dietary restriction (DR) extends lifespan in diverse organisms and, in animal and cellular models, can delay a range of aging-related diseases including Alzheimer's disease (A...
PTEN, a negative regulator of PI3 kinase signalling, alters tau phosphorylation in cells by mechanisms independent of GSK-3
Journal Article
Kerr, F., Rickle, A., Nayeem, N., Brandner, S., Cowburn, R. F., & Lovestone, S. (2006)
PTEN, a negative regulator of PI3 kinase signalling, alters tau phosphorylation in cells by mechanisms independent of GSK-3. FEBS Letters, 580(13), 3121-3128. https://doi.org/10.1016/j.febslet.2006.04.064
Deregulation of PTEN/Akt signalling has been recently implicated in the pathogenesis of Alzheimer's disease (AD), but the effects on the molecular processes underlying AD path...
School Students as Drosophila Experimenters
Journal Article
Siyad, F., Griffiths, J., Janjua, F., Jackson, E., Rodrigues, I., Kerr, F., …Lovestone, S. (2005)
School Students as Drosophila Experimenters. PLoS Biology, 3(7), https://doi.org/10.1371/journal.pbio.0030246
School students as Drosophila experimenters.
Glycogen synthase kinase-3 is increased in white cells early in Alzheimer's disease
Journal Article
Hye, A., Kerr, F., Archer, N., Foy, C., Poppe, M., Brown, R., …Lovestone, S. (2004)
Glycogen synthase kinase-3 is increased in white cells early in Alzheimer's disease. Neuroscience Letters, 373(1), 1-4. https://doi.org/10.1016/j.neulet.2004.10.031
Alzheimer's disease (AD) is a disorder without a molecular marker in peripheral tissues or a disease modifying treatment. As increasing evidence has suggested a role for glyco...