Antioxidant and cytoprotective responses to redox stress
Journal Article
Mathers, J., Fraser, J. A., McMahon, M., Saunders, R. D. C., Hayes, J. D., & McLellan, L. I. (2004)
Antioxidant and cytoprotective responses to redox stress. Biochemical Society symposia, 71, 157-176. https://doi.org/10.1042/bss0710157
Aerobic cells produce reactive oxygen species as a consequence of normal cellular metabolism, and an array of antioxidant systems are in place to maintain the redox balance. W...
Drosophila melanogasterGlutamate-Cysteine Ligase Activity Is Regulated by a Modifier Subunit with a Mechanism of Action Similar to That of the Mammalian Form
Journal Article
Fraser, J. A., Saunders, R. D. C., & McLellan, L. I. (2002)
Drosophila melanogasterGlutamate-Cysteine Ligase Activity Is Regulated by a Modifier Subunit with a Mechanism of Action Similar to That of the Mammalian Form. Journal of Biological Chemistry, 277(2), 1158-1165. https://doi.org/10.1074/jbc.m106683200
Glutamate-cysteine ligase (GCL) plays an important role in regulating glutathione homeostasis. In mammals, it comprises a catalytic (GCLC) and modifier (GCLM) subunit. The exi...
Cloning and functional pharmacology of two corticotropin-releasing factor receptors from a teleost fish
Journal Article
Pohl, S., Darlison, M. G., Clarke, W., Lederis, K., & Richter, D. (2001)
Cloning and functional pharmacology of two corticotropin-releasing factor receptors from a teleost fish. European Journal of Pharmacology, 430(2-3), 193-202. https://doi.org/10.1016/S0014-2999%2801%2901391-7
Although it is well established that fish possess corticotropin-releasing factor (CRF) and a CRF-like peptide, urotensin I, comparatively little is known about the pharmacolog...
Functional pharmacology of GABAA receptors containing the chicken brain γ4 subunit
Journal Article
Forster, I. C., Harvey, R. J., Darlison, M. G., & Benson, J. A. (2001)
Functional pharmacology of GABAA receptors containing the chicken brain γ4 subunit. European Journal of Pharmacology, 419(1), 1-7. https://doi.org/10.1016/S0014-2999%2801%2900964-5
The functional pharmacology of receptors composed of the chicken brain {GABAA} receptor γ4 subunit and the mammalian {GABAA} receptor α3 and β2 subunits was studied by heterol...
The ‘Chicken and Egg’ Problem of Co-evolution of Peptides and Their Cognate Receptors: Which Came First?
Book Chapter
Darlison, M. G., & Richter, D. (1999)
The ‘Chicken and Egg’ Problem of Co-evolution of Peptides and Their Cognate Receptors: Which Came First?. In D. Richter (Ed.), Regulatory Peptides and Cognate Receptors (1-11). Berlin: Springer. https://doi.org/10.1007/978-3-540-49421-8_1
As will be evident from the other chapters in this Volume, small peptide molecules regulate a wide variety of biological processes in both vertebrate and invertebrate species....
Genetic linkage and radiation hybrid mapping of the three human GABAC receptor ρ subunit genes: GABRR1, GABRR2 and GABRR3
Journal Article
Bailey, M. E., Albrecht, B. E., Johnson, K. J., & Darlison, M. G. (1999)
Genetic linkage and radiation hybrid mapping of the three human GABAC receptor ρ subunit genes: GABRR1, GABRR2 and GABRR3. BBA - Gene Structure and Expression, 1447(2-3), 307-312. https://doi.org/10.1016/s0167-4781%2899%2900167-0
{GABAC} receptors mediate rapid inhibitory neurotransmission in retina. We have mapped, in detail, the human genes which encode the three polypeptides that comprise this recep...
Genomic mapping and evolution of human GABAA receptor subunit gene clusters
Journal Article
Bailey, M. E. S., Matthews, D. A., Riley, B. P., Albrecht, B. E., Kostrzewa, M., Hicks, A. A., …Johnson, K. J. (1999)
Genomic mapping and evolution of human GABAA receptor subunit gene clusters. Mammalian Genome, 10(8), 839-843. https://doi.org/10.1007/s003359901101
No abstract available.
Multiple genes for neuropeptides and their receptors: co-evolution and physiology
Journal Article
Darlison, M. G., & Richter, D. (1999)
Multiple genes for neuropeptides and their receptors: co-evolution and physiology. Trends in Neurosciences, 22(2), 81-88. https://doi.org/10.1016/S0166-2236%2898%2901333-2
It is now well established that neuropeptide receptors, which are present throughout the {CNS} and in peripheral tissues, frequently exist in a variety of different forms (cal...
Expression of the GABAA receptor gamma4-subunit gene: anatomical distribution of the corresponding mRNA in the domestic chick forebrain and the effect of imprinting training
Journal Article
Harvey, R. J., McCabe, B. J., Solomonia, R. O., Horn, G., & Darlison, M. G. (1998)
Expression of the GABAA receptor gamma4-subunit gene: anatomical distribution of the corresponding mRNA in the domestic chick forebrain and the effect of imprinting training. The European journal of neuroscience, 10(9), 3024-3028. https://doi.org/10.1046/j.1460-9568.1998.00354.x
The learning process of imprinting involves morphological, electrophysiological and biochemical changes in a region of the chick (Gallus gallus domesticus) forebrain known as ...
Chicken GABAA receptor β4 subunits form robust homomeric GABA-gated channels in Xenopus oocytes
Journal Article
Liu, S., Parent, L., Harvey, R. J., Darlison, M. G., & Eugene, J. M. B. (1998)
Chicken GABAA receptor β4 subunits form robust homomeric GABA-gated channels in Xenopus oocytes. European Journal of Pharmacology, 354(2-3), 253-259. https://doi.org/10.1016/S0014-2999%2898%2900453-1
Chicken {GABAA} receptor β4L and β4S subunits were expressed in Xenopus oocytes by cRNA injection. Oocytes expressing either β4 subunit alone or in combination with the chicke...