Urinary specific gravity as an alternative for the normalisation of endocrine metabolite concentrations in giant panda (Ailuropoda melanoleuca) reproductive monitoring
Journal Article
Wauters, J., Wilson, K. S., Bouts, T., Valentine, I., Vanderschueren, K., Ververs, C., …Vanhaecke, L. (2018)
Urinary specific gravity as an alternative for the normalisation of endocrine metabolite concentrations in giant panda (Ailuropoda melanoleuca) reproductive monitoring. PLOS ONE, 13(7), https://doi.org/10.1371/journal.pone.0201420
Reproductive monitoring for captive breeding in giant pandas is based on behavioural observation and non-invasive hormone analysis. In urine, interpretation of results require...
Ovine trophoblasts express cathelicidin host defence peptide in response to infection
Journal Article
Coyle, C., Wheelhouse, N., Jacques, M., Longbottom, D., Svoboda, P., Pohl, J., …Barlow, P. G. (2016)
Ovine trophoblasts express cathelicidin host defence peptide in response to infection. Journal of Reproductive Immunology, 117, 10-16. https://doi.org/10.1016/j.jri.2016.06.006
Cationic host defence peptides (CHDP; also known as antimicrobial peptides) are key components of the immune response in the female reproductive tract. The role of the placent...
Glucocorticoid receptor-mediated regulation of MMP9 gene expression in human ovarian surface epithelial cells
Journal Article
Rae, M. T., Price, D., Harlow, C. R., Critchley, H. O. D., & Hillier, S. G. (2009)
Glucocorticoid receptor-mediated regulation of MMP9 gene expression in human ovarian surface epithelial cells. Fertility and Sterility, 92(2), 703-708. https://doi.org/10.1016/j.fertnstert.2008.06.040
Objective
To obtain proof-of-concept that locally produced anti-inflammatory steroids suppress ovulation-associated extracellular matrix proteases in human ovarian surface epi...
Effects of maternal undernutrition during early pregnancy on apoptosis regulators in the ovine fetal ovary.
Journal Article
Lea, R. G., Andrade, L. P., Rae, M. T., Hannah, L. T., Kyle, C. E., Murray, J. F., …Miller, D. W. (2006)
Effects of maternal undernutrition during early pregnancy on apoptosis regulators in the ovine fetal ovary. Reproduction, 131, 113-124. https://doi.org/10.1530/rep.1.00844
This study aimed to determine whether reduced fetal ovary folliculogenesis in ewes undernourished during early/midpregnancy is associated with altered ovarian cell proliferati...
Oestrogen formation and connective tissue growth factor expression in rat granulosa cells
Journal Article
Harlow, C. R., Bradshaw, A. C., Rae, M. T., Shearer, K. D., & Hillier, S. G. (2007)
Oestrogen formation and connective tissue growth factor expression in rat granulosa cells. Journal of Endocrinology, 192(1), 41-52. https://doi.org/10.1677/joe.1.06689
Ovarian follicular development involves continual remodelling of the extracellular matrix (ECM) forming the basement membrane and intercellular framework that support granulos...
Maternal nutrient restriction in early pregnancy programs hepatic mRNA expression of growth-related genes and liver size in adult male sheep
Journal Article
Hyatt, M. A., Gopalakrishnan, G. S., Bispham, J., Gentili, S., McMillen, I. C., Rhind, S. M., …Symonds, M. E. (2007)
Maternal nutrient restriction in early pregnancy programs hepatic mRNA expression of growth-related genes and liver size in adult male sheep. Journal of Endocrinology, 192(1), 87-97. https://doi.org/10.1677/joe.1.06801
The liver is a major metabolic and endocrine organ of critical importance in the regulation of growth and metabolism. Its function is determined by a complex interaction of nu...
cAMP response element-binding (CREB) signalling and ovarian surface epithelial cell survival
Journal Article
Gubbay, O., Rae, M. T., McNeilly, A. S., Donadeu, F. X., Zeleznik, A. J., & Hillier, S. G. (2006)
cAMP response element-binding (CREB) signalling and ovarian surface epithelial cell survival. Journal of Endocrinology, 191(1), 275-285. https://doi.org/10.1677/joe.1.06928
cAMP response-element binding (CREB) transcription factors transduce cell survival responses to peptide hormones and growth factors in normal tissues and mutant CREB proteins ...
Steroid signalling in the ovarian surface epithelium
Journal Article
Rae, M. T., & Hillier, S. G. (2005)
Steroid signalling in the ovarian surface epithelium. Trends in Endocrinology and Metabolism, 16(7), 327-333. https://doi.org/10.1016/j.tem.2005.07.002
Human ovarian surface epithelium (HOSE) undergoes serial injury-repair with each ovulation, which is probably why most ovarian epithelial cancers arise there. Considering the ...
Impact of maternal undernutrition and fetal number on glucocorticoid, growth hormone and insulin-like growth factor receptor mRNA abundance in the ovine fetal kidney
Journal Article
Brennan, K. A., Gopalakrishnan, G. S., Kurlak, L., Rhind, S. M., Kyle, C. E., Brooks, A. N., …Symonds, M. E. (2005)
Impact of maternal undernutrition and fetal number on glucocorticoid, growth hormone and insulin-like growth factor receptor mRNA abundance in the ovine fetal kidney. Reproduction, 129, 151-159. https://doi.org/10.1530/rep.1.00229
Epidemiological and animal studies strongly indicate that the environment experienced in utero determines, in part, an individual’s likelihood of developing cardiovascular dis...
Antiinflammatory Steroid Action in Human Ovarian Surface Epithelial Cells
Journal Article
Hillier, S. G., Rae, M. T., Niven, D., Critchley, H. O. D., & Harlow, C. R. (2004)
Antiinflammatory Steroid Action in Human Ovarian Surface Epithelial Cells. Journal of Clinical Endocrinology and Metabolism, 89(9), 4538-4544. https://doi.org/10.1210/jc.2003-032225
The human ovarian surface epithelium (OSE) is subject to
serial injury and repair during ovulation, which is a natural inflammatory event. We asked whether there is a compensa...