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58 results

Regional cerebral blood flow in IDDM patients: effects of diabetes and of recurrent severe hypoglycaemia

Journal Article
MacLeod, K. M., Hepburn, D. A., Deary, I. J., Goodwin, G. M., Dougall, N., Ebmeier, K. P. & Frier, B. M. (1994)
Regional cerebral blood flow in IDDM patients: effects of diabetes and of recurrent severe hypoglycaemia. Diabetologia. 37(3), 257-263. doi:10.1007/s001250050103. ISSN 0012-186X
Chronic hyperglycaemia and recurrent severe hypoglycaemia have both been implicated as causing cerebral damage in patients with diabetes. Although cognitive dysfunction and in...

Clonidine infusion increases uptake of 99mTc-Exametazime in anterior cingulate cortex in Korsakoff's psychosis

Journal Article
Moffoot, A., O'Carroll, R. E., Murray, C., Dougall, N., Ebmeier, K. & Goodwin, G. M. (1994)
Clonidine infusion increases uptake of 99mTc-Exametazime in anterior cingulate cortex in Korsakoff's psychosis. Psychological Medicine. 24(01), 53. doi:10.1017/s0033291700026829. ISSN 0033-2917
The effects upon regional brain function of infusing either saline or clonidine (1·5μg/kg) has been examined in 18 patients with alcoholic Korsakoff's psychosis using 99mTc-he...

Short-term effects of electroconvulsive treatment on the uptake of99mTc-Exametazime into brain in major depression shown with single photon emission tomography

Journal Article
Scott, A. I. F., Dougall, N., Ross, M., O'Carroll, R. E., Riddle, W., Ebmeier, K. P. & Goodwin, G. M. (1993)
Short-term effects of electroconvulsive treatment on the uptake of99mTc-Exametazime into brain in major depression shown with single photon emission tomography. Journal of Affective Disorders. 30(1), 27-34. doi:10.1016/0165-0327(94)90148-1. ISSN 0165-0327
Fifteen patients with major depression who were being treated with bilateral electroconvulsive treatment (ECT) were investigated before and 45 min after a single ECT using spl...

The effect of anxiety induction on the regional uptake of 99mTc-Exametazime in simple phobia as shown by single photon emission tomography (SPET)

Journal Article
O'Carroll, R. E., Moffoot, A. P. R., Van Beck, M., Dougall, N., Murray, C., Ebmeier, K. P. & Goodwin, G. M. (1993)
The effect of anxiety induction on the regional uptake of 99mTc-Exametazime in simple phobia as shown by single photon emission tomography (SPET). Journal of Affective Disorders. 28(3), 203-210. doi:10.1016/0165-0327(93)90106-t. ISSN 0165-0327
Ten patients suffering from DSM-III-R simple phobia were studied under two conditions: (a) while listening to a 4 min relaxation tape, and (b) while listening to a 4 min audio...

Single-photon emission computed tomography with 99mTc-exametazime in unmediated schizophrenic patients

Journal Article
Ebmeier, K. P., Blackwood, D. H. R., Murray, C., Souza, V., Walker, M., Dougall, N., …Goodwin, G. M. (1993)
Single-photon emission computed tomography with 99mTc-exametazime in unmediated schizophrenic patients. Biological Psychiatry. 33(7), 487-495. doi:10.1016/0006-3223(93)90002-u. ISSN 0006-3223
We examined 20 actively psychotic unmedicated schizophrenic patients and 20 matched control subjects by using single-photon emission, computed tomography (SPECT) with 99mtechn...

Unilateral voluntary hand movement and regional cerebral uptake of technetium-99m-exametazime in human control subjects

Journal Article
Dougall, N. (1992)
Unilateral voluntary hand movement and regional cerebral uptake of technetium-99m-exametazime in human control subjects. Journal of Nuclear Medicine. 33(9), 1623-1627. ISSN 0161-5505

Single photon emission tomography with 99mTc-exametazime in major depression and the pattern of brain activity underlying the psychotic/neurotic continuum

Journal Article
Austin, M., Dougall, N., Ross, M., Murray, C., O'Carroll, R. E., Moffoot, A., …Goodwin, G. M. (1992)
Single photon emission tomography with 99mTc-exametazime in major depression and the pattern of brain activity underlying the psychotic/neurotic continuum. Journal of Affective Disorders. 26(1), 31-43. doi:10.1016/0165-0327(92)90032-2. ISSN 0165-0327
Forty patients with a major depressive episode were investigated at rest using Single Photon Emission Tomography (SPET or SPECT) with 99mTc-exametazime, an intravenous ligand ...

Regional cerebral blood flow and cognitive function in patients with chronic liver disease

Journal Article
O'Carroll, R. E., Ebmeier, K. P., Dougall, N., Murray, C., Goodwin, G. M., Hayes, P. C., …Best, J. J. K. (1991)
Regional cerebral blood flow and cognitive function in patients with chronic liver disease. Lancet. 337(8752), 1250-1253. doi:10.1016/0140-6736(91)92920-w. ISSN 0140-6736
Subtle impairments of cognitive function may be an important cause of occupational and psychosocial morbidity in patients with chronic liver disease. Correlation of structural...

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18 results

Assessing the implementation of the Public Health Scotland Physical Activity Referral Standards: A process evaluation

2022 - 2025
Physical inactivity is a major public health problem and increasing population physical activity levels is a Scottish Government priority. In Scotland, 49% of men and 58% of women were not active enou...
Funder: Chief Scientists Office | Value: £298,277

Mental health and substance use care pathways and outcomes for people released from prison

2022 - 2024
Lay summary: It is important that people released from prison get help for mental health and substance use. This will protect their health and help them live life away from crime. People released from...
Funder: Chief Scientists Office | Value: £42,581

Naloxone in Police Scotland - a Pilot Evaluation

2022 - 2022
This study will be a mixed methods process evaluation of a test of change (pilot project) for the carriage, and use, of intra-nasal spray Naloxone by Police Scotland officers. The evaluation will foc...
Funder: Scottish Government | Value: £80,769

A realist evaluation of the implementation of a Continuous Intervention Policy in inpatient mental health services in Scotland.

2020 - 2025
A realist evaluation of the implementation of a Continuous Intervention Policy in inpatient mental health services in Scotland. NHS Boards in Scotland are implementing new observation policies in line...
Funder: NHS Lothian | Value: £4,743

Accelerating the development of a psychological intervention to support treatment decision-making capacity in psychosis: Feasibility of an Umbrella trial.

2019 - 2023
Clinicians are legally and ethically obliged to respect patients’ autonomy and the decisions patients make about their treatment, unless they lack “capacity” for such decision making. In the last 10 ...
Funder: Chief Scientists Office | Value: £309,226

HEADS: UP (Helping Ease Anxiety and Depression following Stroke) psychological self-management intervention: non-randomised pilot study followed by a randomised cluster pilot trial.

2019 - 2023
The aim of this mixed methods research is to conduct feasibility pilot testing of a tailored adaptation of an existing psychological intervention to help people affected by stroke self-manage symptoms...
Funder: Stroke Association | Value: £5,181

Eye Movement Desensitisation and Reprocessing (EMDR) for post-traumatic stress disorder (PTSD) post perinatal loss: investigating final details for pilot trial and feasibility study

2019 - 2019
Approximately 3,500 women in the UK experience the trauma of perinatal loss each year. Up to 39% go on to develop perinatal PTSD. There is no effective treatment for these women, but EMDR is effective...
Funder: Chief Scientists Office | Value: £33,319

The role of CHildhood Adversities and their subsequent effect on mental ill-health and Suicidal behaviour (CHASe)

2018 - 2020
Deaths by suicide among young people are common, increasing year by year in 15-19 year olds, have devastating consequences for everyone involved, and are a signficant UK public health problem. People ...
Funder: Chief Scientists Office | Value: £80,064

Law enforcement and public health: Assessing risk and vulnerability

2017 - 2018
The aim of the project is to conduct a systematic review and host round-table discussions to explore the use of police discretion when making decisions in relation to individuals' vulnerability.
Funder: Scottish Institute for Policing Research | Value: £7,986

Acceptability of extragenital Chlamydia testing

2017 - 2018
Chlamydia trachomatis is the most common sexually transmitted infection in Scotland, and has significant long‐term consequences to reproductive health. Recent studies suggest that in addition to the g...
Funder: Chief Scientists Office | Value: £27,998