Invertebrate GABA and glutamate receptors: molecular biology reveals predictable structures but some unusual pharmacologies
Journal Article
Darlison, M. G. (1992)
Invertebrate GABA and glutamate receptors: molecular biology reveals predictable structures but some unusual pharmacologies. Trends in Neurosciences, 15(12), 469-474. https://doi.org/10.1016/0166-2236%2892%2990091-l
Determination of the sequences of invertebrate γ-aminobutyric acid (GABA)-gated and glutamate-gated receptor/ion channels, through the application of recombinant {DNA} methods...
Confirmation of the localization of the human GABAA receptor α1-subunit gene (GABRA1) to distal 5q by linkage analysis
Journal Article
Johnson, K. J., Sander, T., Hicks, A. A., van Marle, A., Janz, D., Mullan, M. J., …Darlison, M. G. (1992)
Confirmation of the localization of the human GABAA receptor α1-subunit gene (GABRA1) to distal 5q by linkage analysis. Genomics, 14(3), 745-748. https://doi.org/10.1016/s0888-7543%2805%2980178-8
The GABAA receptor is the major inhibitory neurotransmitter receptor in the mammalian brain. To date, 14 genes that encode subunits of this receptor have been identified; thes...
GABAA receptor subunit genes as candidate genes for bipolar affective disorder—an association analysis
Journal Article
Walsh, C., Hicks, A. A., Sham, P., Castle, D., Hunt, N., Clements, A., …Gill, M. (1992)
GABAA receptor subunit genes as candidate genes for bipolar affective disorder—an association analysis. Psychiatric Genetics, 2(4), 239-248. https://doi.org/10.1097/00041444-199210000-00002
Polymorphic DNA segments can be used as genetic markers to test for allelic association between a disease and a candidate gene locus. Here we report the results of a study of ...
Unusual effects of benzodiazepines and cyclodiene insecticides on an expressed invertebrate GABAAreceptor
Journal Article
Zaman, S. H., Harvey, R. J., Barnard, E. A., & Darlison, M. G. (1992)
Unusual effects of benzodiazepines and cyclodiene insecticides on an expressed invertebrate GABAAreceptor. FEBS Letters, 307(3), 351-354. https://doi.org/10.1016/0014-5793%2892%2980711-o
We have previously reported [(1991) EMBO J. 10, 3239–3245] the sequence of an invertebrate γ‐aminobutyric acid (GABA) type A (GABAA) receptor polypeptide which forms homo‐olig...
Fine mapping of the human biglycan (BGN) gene within the Xq28 region employing a hybrid cell panel
Journal Article
Traupe, H., Ouweland, A. M. V. D., Oost, B. A. V., Vogel, W., Vetter, U., Warren, S. T., …Ropers, H. (1992)
Fine mapping of the human biglycan (BGN) gene within the Xq28 region employing a hybrid cell panel. Genomics, 13(2), 481-483. https://doi.org/10.1016/0888-7543%2892%2990279-2
Human biglycan is a small proteoglycan that is expressed at high levels in the growing skeleton and in human skin at the cell surface of differentiating keratinocytes. The hum...
Effects of subunit types of the recombinant GABAA receptor on the response to a neurosteroid
Journal Article
Zaman, S. H., Shingai, R., Harvey, R. J., Darlison, M. G., & Barnard, E. A. (1992)
Effects of subunit types of the recombinant GABAA receptor on the response to a neurosteroid. European journal of pharmacology. Molecular pharmacology section, 225(4), 321-330. https://doi.org/10.1016/0922-4106%2892%2990106-6
When vertebrate brain poly(A)+ RNA is expressed in Xenopus oocytes the response of the GABA receptors formed is found to be inhibited allosterically by a neurosteroid, pregnen...
Differential Localization of Two Alternatively Spliced GABAAReceptor γ2-Subunit mRNAs in the Chick Brain
Journal Article
Glencorse, T. A., Bateson, A. N., & Darlison, M. G. (1992)
Differential Localization of Two Alternatively Spliced GABAAReceptor γ2-Subunit mRNAs in the Chick Brain. European Journal of Neuroscience, 4(3), 271-277. https://doi.org/10.1111/j.1460-9568.1992.tb00874.x
Two variants of the GABAA receptor γ2 subunit are known to exist, which differ by the presence (γ2L) or absence (γ2S) of eight amino acids in the presumed intracellular loop b...
Dinucleotide repeat polymorphism in the human X-linked GABAAreceptora3-subunit gene
Journal Article
Hicks, A. A., Johnson, K. J., Barnard, E. A., & Darlison, M. G. (1991)
Dinucleotide repeat polymorphism in the human X-linked GABAAreceptora3-subunit gene. Nucleic Acids Research, 19(14), 4016-4016. https://doi.org/10.1093/nar/19.14.4016
No abstract available.
Random-primed cDNA synthesis facilitates the isolation of multiple 5'-cDNA ends by RACE
Journal Article
Harvey, R. J., & Darlison, M. G. (1991)
Random-primed cDNA synthesis facilitates the isolation of multiple 5'-cDNA ends by RACE. Nucleic Acids Research, 19(14), 4002-4002. https://doi.org/10.1093/nar/19.14.4002
No abstract available.
Distribution of the GABAA receptor α1- and γ2-subunit mRNAs in chick brain
Journal Article
Glencorse, T. A., Bateson, A. N., Hunt, S. P., & Darlison, M. G. (1991)
Distribution of the GABAA receptor α1- and γ2-subunit mRNAs in chick brain. Neuroscience Letters, 133(1), 45-48. https://doi.org/10.1016/0304-3940%2891%2990053-v
We have used sequence-specific oligonucleotide probes and in situ hybridisation histochemistry to examine the distributions of the GABAA receptor α1- and γ2-subunit mRNAs in s...