Conservation of γ-Aminobutyric Acid Type A Receptor α6 Subunit Gene Expression in Cerebellar Granule Cells
Journal Article
Bahn, S., Harvey, R. J., Darlison, M. G., & Wisden, W. (1996)
Conservation of γ-Aminobutyric Acid Type A Receptor α6 Subunit Gene Expression in Cerebellar Granule Cells. Journal of Neurochemistry, 66(5), 1810-1818. https://doi.org/10.1046/j.1471-4159.1996.66051810.x
The γ-aminobutyric acid type A receptor cDNAs encoding the α6 subunit homologues from chicken and goldfish have been cloned and sequenced. These proteins exhibit 83 and 75% id...
Channel gating in the absence of agonist by a homooligomeric molluscan GABA receptor expressed inXenopus oocytes from a cloned cDNA
Journal Article
Bhandal, N. S., Ramsey, R. L., Harvey, R. J., Darlison, M. G., & Usherwood, P. N. R. (1995)
Channel gating in the absence of agonist by a homooligomeric molluscan GABA receptor expressed inXenopus oocytes from a cloned cDNA. Invertebrate Neuroscience, 1(3), 267-272. https://doi.org/10.1007/bf02211028
We have previously described the isolation of a complementary DNA (cDNA) from the freshwater molluscLymnaea stagnalis encoding a polypeptide that exhibits ∼50{%} identity to t...
Analysis of GABAA receptor subunit genes in multiplex pedigrees with manic depression
Journal Article
Coon, H., Hicks, A. A., Bailey, M. E., Hoff, M., Holik, J., Harvey, R. J., …Byerley, W. (1994)
Analysis of GABAA receptor subunit genes in multiplex pedigrees with manic depression. Psychiatric Genetics, 4(3), 185-191. https://doi.org/10.1097/00041444-199400430-00009
The gamma-aminobutyric acid (GABA) neurotransmitter system has been implicated in the pathogenesis of manic depression. Tests of this hypothesis can now be carried out due to ...
Sequence of a Drosophila Ligand-Gated Ion-Channel Polypeptide with an Unusual Amino-Terminal Extracellular Domain
Journal Article
Harvey, R. J., Schmitt, B., Hermans-Borgmeyer, I., Gundelfinger, E. D., Betz, H., & Darlison, M. G. (1994)
Sequence of a Drosophila Ligand-Gated Ion-Channel Polypeptide with an Unusual Amino-Terminal Extracellular Domain. Journal of Neurochemistry, 62(6), 2480-2483. https://doi.org/10.1046/j.1471-4159.1994.62062480.x
Abstract: We report the isolation of a full-length clone from a Drosophila melanogaster head cDNA library that encodes a 614-residue polypeptide that exhibits all of the featu...
Multiplicity, Structure, and Function in GABAAReceptors
Journal Article
BARNARD, E. A., SUTHERLAND, M., ZAMAN, S., MATSUMOTO, M., NAYEEM, N., GREEN, T., …BATESON, A. N. (1993)
Multiplicity, Structure, and Function in GABAAReceptors. Annals of the New York Academy of Sciences, 707(1 Molecular Bas), 116-125. https://doi.org/10.1111/j.1749-6632.1993.tb38047.x
No abstract available.
Differential distribution of GABAA receptor mRNAs in bovine cerebellum — Localization of α2 mRNA in Bergmann glia layer
Journal Article
Wisden, W., McNaughton, L. A., Darlison, M. G., Hunt, S. P., & Barnard, E. A. (1989)
Differential distribution of GABAA receptor mRNAs in bovine cerebellum — Localization of α2 mRNA in Bergmann glia layer. Neuroscience Letters, 106(1-2), 7-12. https://doi.org/10.1016/0304-3940%2889%2990193-6
Using in situ hybridization histochemistry, we have demonstrated that 3 α subunit mRNAs of the {GABAA} receptor are present in different cell populations of the bovine cerebel...
Distinct GABAA receptor α subunit mRNAs show differential patterns of expression in bovine brain
Journal Article
Wisden, W., Morris, B. J., Darlison, M. G., Hunt, S. P., & Barnard, E. A. (1988)
Distinct GABAA receptor α subunit mRNAs show differential patterns of expression in bovine brain. Neuron, 1(10), 937-947. https://doi.org/10.1016/0896-6273%2888%2990151-1
Specific oligonucleotide probes have been used to visualize the regional and cellular distribution of the mRNAs encoding three structurally distinct GABA A receptor α subunits...
Structural and functional basis for GABAA receptor heterogeneity
Journal Article
Levitan, E. S., Schofield, P. R., Burt, D. R., Rhee, L. M., Wisden, W., Köhler, M., …Seeburg, P. H. (1988)
Structural and functional basis for GABAA receptor heterogeneity. Nature, 335(6185), 76-79. https://doi.org/10.1038/335076a0
When γ-aminobutyric acid (GABA), the major inhibitory neurotransmitter in vertebrate brain, binds to its receptor it activates a chloride channel. Neurotransmitter action at t...