Sequence and Novel Distribution of the Chicken Homologue of the Mammalianγ-Aminobutyric AcidAReceptorγ1 Subunit
Journal Article
Glencorse, T. A., Darlison, M. G., Barnard, E. A., & Bateson, A. N. (1993)
Sequence and Novel Distribution of the Chicken Homologue of the Mammalianγ-Aminobutyric AcidAReceptorγ1 Subunit. Journal of Neurochemistry, 61(6), 2294-2302. https://doi.org/10.1111/j.1471-4159.1993.tb07473.x
cDNAs have been cloned that encode the chicken (Gallus domesticus) γ-aminobutyric acidA receptor γ1 subunit, the mature sequence of which shares 90, 79, and 69% identity with ...
Molluscan ligand-gated ion-channel receptors
Book Chapter
Darlison, M. G., Hutton, M. L., & Harvey, R. J. (1993)
Molluscan ligand-gated ion-channel receptors. In Comparative Molecular Neurobiology, 48-64. Springer Verlag. https://doi.org/10.1007/978-3-0348-7265-2_3
In this chapter we introduce the reader to the structures of the different types of ligand-gated ion-channel receptor, and the numerous receptor subtypes that have recently be...
Rheological spectroscopy of concentrated colloidal dispersions
Journal Article
Williams, P., Williams, D., & Williams, R. (1993)
Rheological spectroscopy of concentrated colloidal dispersions. Colloids and Surfaces A: Physicochemical and Engineering Aspects, 77(1), 75-79. https://doi.org/10.1016/0927-7757%2893%2980101-j
A new instrument, the virtual gap rheometer (VGR) for the determination of dynamic shear moduli (and mechanical relaxation spectra therefrom) at frequencies above 100 Hz is de...
Invertebrate GABA and glutamate receptors: molecular biology reveals predictable structures but some unusual pharmacologies
Journal Article
Darlison, M. G. (1992)
Invertebrate GABA and glutamate receptors: molecular biology reveals predictable structures but some unusual pharmacologies. Trends in Neurosciences, 15(12), 469-474. https://doi.org/10.1016/0166-2236%2892%2990091-l
Determination of the sequences of invertebrate γ-aminobutyric acid (GABA)-gated and glutamate-gated receptor/ion channels, through the application of recombinant {DNA} methods...
Confirmation of the localization of the human GABAA receptor α1-subunit gene (GABRA1) to distal 5q by linkage analysis
Journal Article
Johnson, K. J., Sander, T., Hicks, A. A., van Marle, A., Janz, D., Mullan, M. J., …Darlison, M. G. (1992)
Confirmation of the localization of the human GABAA receptor α1-subunit gene (GABRA1) to distal 5q by linkage analysis. Genomics, 14(3), 745-748. https://doi.org/10.1016/s0888-7543%2805%2980178-8
The GABAA receptor is the major inhibitory neurotransmitter receptor in the mammalian brain. To date, 14 genes that encode subunits of this receptor have been identified; thes...
GABAA receptor subunit genes as candidate genes for bipolar affective disorder—an association analysis
Journal Article
Walsh, C., Hicks, A. A., Sham, P., Castle, D., Hunt, N., Clements, A., …Gill, M. (1992)
GABAA receptor subunit genes as candidate genes for bipolar affective disorder—an association analysis. Psychiatric Genetics, 2(4), 239-248. https://doi.org/10.1097/00041444-199210000-00002
Polymorphic DNA segments can be used as genetic markers to test for allelic association between a disease and a candidate gene locus. Here we report the results of a study of ...
Unusual effects of benzodiazepines and cyclodiene insecticides on an expressed invertebrate GABAAreceptor
Journal Article
Zaman, S. H., Harvey, R. J., Barnard, E. A., & Darlison, M. G. (1992)
Unusual effects of benzodiazepines and cyclodiene insecticides on an expressed invertebrate GABAAreceptor. FEBS Letters, 307(3), 351-354. https://doi.org/10.1016/0014-5793%2892%2980711-o
We have previously reported [(1991) EMBO J. 10, 3239–3245] the sequence of an invertebrate γ‐aminobutyric acid (GABA) type A (GABAA) receptor polypeptide which forms homo‐olig...
Fine mapping of the human biglycan (BGN) gene within the Xq28 region employing a hybrid cell panel
Journal Article
Traupe, H., Ouweland, A. M. V. D., Oost, B. A. V., Vogel, W., Vetter, U., Warren, S. T., …Ropers, H. (1992)
Fine mapping of the human biglycan (BGN) gene within the Xq28 region employing a hybrid cell panel. Genomics, 13(2), 481-483. https://doi.org/10.1016/0888-7543%2892%2990279-2
Human biglycan is a small proteoglycan that is expressed at high levels in the growing skeleton and in human skin at the cell surface of differentiating keratinocytes. The hum...
Effects of subunit types of the recombinant GABAA receptor on the response to a neurosteroid
Journal Article
Zaman, S. H., Shingai, R., Harvey, R. J., Darlison, M. G., & Barnard, E. A. (1992)
Effects of subunit types of the recombinant GABAA receptor on the response to a neurosteroid. European journal of pharmacology. Molecular pharmacology section, 225(4), 321-330. https://doi.org/10.1016/0922-4106%2892%2990106-6
When vertebrate brain poly(A)+ RNA is expressed in Xenopus oocytes the response of the GABA receptors formed is found to be inhibited allosterically by a neurosteroid, pregnen...
Differential Localization of Two Alternatively Spliced GABAAReceptor γ2-Subunit mRNAs in the Chick Brain
Journal Article
Glencorse, T. A., Bateson, A. N., & Darlison, M. G. (1992)
Differential Localization of Two Alternatively Spliced GABAAReceptor γ2-Subunit mRNAs in the Chick Brain. European Journal of Neuroscience, 4(3), 271-277. https://doi.org/10.1111/j.1460-9568.1992.tb00874.x
Two variants of the GABAA receptor γ2 subunit are known to exist, which differ by the presence (γ2L) or absence (γ2S) of eight amino acids in the presumed intracellular loop b...