The ‘Chicken and Egg’ Problem of Co-evolution of Peptides and Their Cognate Receptors: Which Came First?
Book Chapter
Darlison, M. G., & Richter, D. (1999)
The ‘Chicken and Egg’ Problem of Co-evolution of Peptides and Their Cognate Receptors: Which Came First?. In D. Richter (Ed.), Regulatory Peptides and Cognate Receptors (1-11). Berlin: Springer. https://doi.org/10.1007/978-3-540-49421-8_1
As will be evident from the other chapters in this Volume, small peptide molecules regulate a wide variety of biological processes in both vertebrate and invertebrate species....
GABA-, Glycine-, and Glutamate-Gated Channels and Their Possible Involvement in Neurological and Psychiatric Illness
Book Chapter
Darlison, M. G., & Harvey, R. J. (1996)
GABA-, Glycine-, and Glutamate-Gated Channels and Their Possible Involvement in Neurological and Psychiatric Illness. In Molecular Biology of Membrane Transport Disorders, 169-180. Springer Verlag. https://doi.org/10.1007/978-1-4613-1143-0_9
Rapid chemical communication between cells in the vertebrate central nervous system is mediated by ligand-gated ion-channel receptors (also called ionotropic receptors), which...
Molecular Characterization of GABA-Gated Chloride Ion Channels from Complex and Simple Nervous Systems
Book Chapter
Darlison, M. G. (1994)
Molecular Characterization of GABA-Gated Chloride Ion Channels from Complex and Simple Nervous Systems. In C. Peracchia (Ed.), Handbook of Membrane Channels, 303-315. Academic Press Books. https://doi.org/10.1016/b978-0-12-550640-3.50025-3
No abstract available.
Molluscan ligand-gated ion-channel receptors
Book Chapter
Darlison, M. G., Hutton, M. L., & Harvey, R. J. (1993)
Molluscan ligand-gated ion-channel receptors. In Comparative Molecular Neurobiology, 48-64. Springer Verlag. https://doi.org/10.1007/978-3-0348-7265-2_3
In this chapter we introduce the reader to the structures of the different types of ligand-gated ion-channel receptor, and the numerous receptor subtypes that have recently be...
The Isolation of Genomic DNA from Invertebrates
Book Chapter
Vreugdenhil, E., & Darlison, M. G. (1992)
The Isolation of Genomic DNA from Invertebrates. In A. Longstaff, & P. Revest (Eds.), Protocols in Molecular Neurobiology, 15-24. Springer Verlag. https://doi.org/10.1385/0-89603-199-3%3A15
Generally, genomic DNA is used either for the construction of genomic libraries or for Southern blot analysis. For several reasons, it is frequently preferable in the field of...
The Structure and Expression of the GABAA Receptor as Deduced by Molecular Genetic Studies
Book Chapter
Darlison, M. G., Barnard, E. A., Bateson, A. N., Glencorse, T. A., Harvey, R. J., Hicks, A. A., …Wisden, W. (1989)
The Structure and Expression of the GABAA Receptor as Deduced by Molecular Genetic Studies. In Molecular Biology of Neuroreceptors and Ion Channels, 83-99. Springer Verlag. https://doi.org/10.1007/978-3-642-74155-5_7
It is well established that the inhibitory neurotransmitter γ-aminobutyric acid (GABA) mediates many of its effects by binding to the GABAA receptor, which is present on the m...
Structural Characteristics of Cation and Anion Channels Directly Operated by Agonists
Book Chapter
BARNARD, E., DARLISON, M., MARSHALL, J., & SATTELLE, D. (1989)
Structural Characteristics of Cation and Anion Channels Directly Operated by Agonists. In Ion Transport, 159-181. Academic Press Books. https://doi.org/10.1016/b978-0-12-403985-8.50016-8
No abstract available.
Molecular Biology of Nicotinic Acetylcholine Receptors from Chicken Muscle and Brain
Book Chapter
Squire, M. D., Moss, S. J., Lai, F. A., Darlison, M. G., Cockcroft, V. B., Barnard, E. A., …Ross, S. J. (1986)
Molecular Biology of Nicotinic Acetylcholine Receptors from Chicken Muscle and Brain. In A. Maelicke (Ed.), Nicotinic Acetylcholine Receptor, 389-415. Springer Verlag. https://doi.org/10.1007/978-3-642-71649-2_30
While it has been completely established that the AChR** as isolated from the electroplaques of electric fish is composed of four different polypeptides, such that its subunit...