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61 results

Design of a New Peptide Substrate Probe of the Putative Biomarker Legumain with Potential Application in Prostate Cancer Diagnosis ex vivo

Journal Article
Mathur, S., Turnbull, A., Akaev, I., Stevens, C., Agrawal, N., Chopra, M., & Mincher, D. (2020)
Design of a New Peptide Substrate Probe of the Putative Biomarker Legumain with Potential Application in Prostate Cancer Diagnosis ex vivo. International Journal of Peptide Research and Therapeutics, 26, 1965-1980. https://doi.org/10.1007/s10989-019-09994-1
The lysosomal endoprotease legumain (asparaginyl endoprotease) has been proposed as a putative biomarker in prostate tumours, in which the enzyme is markedly overexpressed. Ov...

Type 1 diabetes patients increase CXCR4+ and CXCR7+ haematopoietic and endothelial progenitor cells with exercise, but the response is attenuated

Journal Article
Taylor, G. S., Shaw, A., Smith, K., Capper, T. E., Scragg, J. H., Cronin, M., …West, D. J. (2021)
Type 1 diabetes patients increase CXCR4+ and CXCR7+ haematopoietic and endothelial progenitor cells with exercise, but the response is attenuated. Scientific Reports, 11, https://doi.org/10.1038/s41598-021-93886-2
Background: Exercise mobilizes angiogenic cells, which stimulate vascular repair. However, limited research suggests exercise-induced increase of endothelial progenitor cell (...

COVID-19 Public Inquiry: Research Report for Portfolio 3 The Provision of Health and Social Care Services Adult Social Care

Report
Report commissioned by Scottish COVID-19 Public Inquiry into the Scottish Government's strategic response to the COVID pandemic in relation to the provision of healthcare serv...

Lymphocyte Apoptosis, Adhesion/activation Molecules And Complement Regulatory Proteins Following Intensive, Moderate And Eccentric Exercise: 1739 11:30 AM - 11:45 AM

Journal Article
Simpson, R. J., Guy, K., Whyte, G. P., & Florida-James, G. D. (2005)
Lymphocyte Apoptosis, Adhesion/activation Molecules And Complement Regulatory Proteins Following Intensive, Moderate And Eccentric Exercise: 1739 11:30 AM - 11:45 AM. Medicine and Science in Sports and Exercise, 37(Supplement), S336. https://doi.org/10.1097/00005768-200505001-01738
No abstract available.

The Effects of Air Pollution Particles on Clearance Mechanisms Within the Lung

Thesis
Barlow, P. G. The Effects of Air Pollution Particles on Clearance Mechanisms Within the Lung. (Thesis)
Edinburgh Napier University. Retrieved from http://researchrepository.napier.ac.uk/Output/1052591
The effects of inhaled aIr pollution particles on lung clearance mechanisms is an important factor in understanding how the mammalian lung deals with such pollutants and, as s...

Missing a trick? Response to: ‘Disinfectant wipes are appropriate to control microbial bioburden from surfaces’

Journal Article
Dancer, S. (2016)
Missing a trick? Response to: ‘Disinfectant wipes are appropriate to control microbial bioburden from surfaces’. Journal of Hospital Infection, 92(2), 208-209. https://doi.org/10.1016/j.jhin.2015.10.020
Letter to Editor. Refers to - J.-Y. Maillard, S.A. Sattar, C. Bradley Missing a trick? Response to: ‘Disinfectant wipes are appropriate to control microbial bioburden from su...

ATP stimulates MDM2-mediated inhibition of the DNA-binding function of E2F1: ATP stimulated inhibition of E2F1 by MDM2

Journal Article
Stevens, C., Pettersson, S., Wawrzynow, B., Wallace, M., Ball, K., Zylicz, A., & Hupp, T. R. (2008)
ATP stimulates MDM2-mediated inhibition of the DNA-binding function of E2F1: ATP stimulated inhibition of E2F1 by MDM2. FEBS Journal, 275(19), 4875-4886. https://doi.org/10.1111/j.1742-4658.2008.06627.x
Murine double minute 2 (MDM2) protein exhibits many diverse biochemical functions on the tumour suppressor protein p53, including transcriptional suppression and E3 ubiquitin ...

Understanding the attitudes and acceptability of extra-genital Chlamydia testing in young women: evaluation of a feasibility study

Journal Article
Brown, S., Paterson, C., Dougall, N., Cameron, S., & Wheelhouse, N. (2019)
Understanding the attitudes and acceptability of extra-genital Chlamydia testing in young women: evaluation of a feasibility study. BMC Public Health, 19(1), https://doi.org/10.1186/s12889-019-7313-0
Background Chlamydia trachomatis (C. trachomatis) is the most common bacterial sexually transmitted infection in the UK. Recent studies suggest that in addition to the genital...

The effectiveness of home versus community-based weight control programmes initiated soon after breast cancer diagnosis: a randomised controlled trial

Journal Article
Harvie, M., Pegington, M., McMullan, D., Bundred, N., Livingstone, K., Campbell, A., …Howell, A. (2019)
The effectiveness of home versus community-based weight control programmes initiated soon after breast cancer diagnosis: a randomised controlled trial. British Journal of Cancer, 121(6), 443–454. https://doi.org/10.1038/s41416-019-0522-6
Background Breast cancer diagnosis may be a teachable moment for lifestyle behaviour change and to prevent adjuvant therapy associated weight gain. We assessed the acceptabili...

Therapeutic Change in Group Therapy For Interpersonal Trauma: A Relational Framework for Research and Clinical Practice

Journal Article
Chouliara, Z., Karatzias, T., Gullone, A., Ferguson, S., Cosgrove, K., & Burke Draucker, C. (2020)
Therapeutic Change in Group Therapy For Interpersonal Trauma: A Relational Framework for Research and Clinical Practice. Journal of Interpersonal Violence, 35(15-16), 2897-2916. https://doi.org/10.1177/0886260517696860
Our understanding of therapeutic change processes in group therapy for complex interpersonal trauma has been limited. The present study aimed at addressing this gap by develop...
29 results

Development of an in vitro suppression assay to assess functionality of therapeutic regulatory T cell for the treatment of rheumatoid arthritis

2023 - 2024
MRS Summer Studentship for ENU Undergrad student Martin Swapp - 8 weeks in duration over summer 2023
Funder: Medical Research Scotland | Value: £3,030

Acceptability of extragenital Chlamydia testing

2017 - 2018
Chlamydia trachomatis is the most common sexually transmitted infection in Scotland, and has significant long‐term consequences to reproductive health. Recent studies suggest that in addition to the g...
Funder: Chief Scientists Office | Value: £27,998

Beltane Public Engagement Fellowships

2015 - 2015
To embed Public Engagement (PE) as a core part of good teaching, learning, research and knowledge exchange.To support staff and students to become confident practitioners in PE by development of a net...
Funder: Beltane Public Engagement | Value: £8,000

Exploiting micofluidic devices for physiologically relavent drug screening against human pathogens

2022 - 2022
Undergraduate student summer project (8 weeks)
Funder: Medical Research Scotland | Value: £2,160

An investigation of commonly used IBD drugs on autophagy pathway activity and potential therapeutic benefit for the treatment of paediatric IBD

2014 - 2017
Recent genetic discoveries, principally identification of NOD2 and ATG16L1 as susceptibility loci, strongly implicate a dysregulated host response to enteric bacteria and the autophagy pathway in the ...
Funder: Crohn's in Childhood Research Association | Value: £68,577

Ranking novel immune-modulating therapeutics for progression to clinical development

2018 - 2019
Ranking novel immune-modulating therapeutics for progression to clinical development
Funder: Scottish Funding Council | Value: £4,987

EEID travel award: Understanding transmission dynamics for bacterial zoonoses in humans, goats and camels among pastoral communities in Northern Kenya

2019 - 2019
EEID travel award: Understanding transmission dynamics for bacterial zoonoses in humans, goats and camels among pastoral communities in Northern Kenya
Funder: Biotechnology and Biological Sciences Research Council | Value: £1,960

Medical Research Scotland Vacation Scholarship

2022 - 2023
Investigating the anti-metastatic potential of Honokiol by attenuating KISS1/ KISS1R signaling
Funder: Medical Research Scotland | Value: £2,160

Host Defence Peptides as novel modulators of autophagy in Inflammatory Bowel Disease

2019 - 2022
Increasing numbers of patients are diagnosed with inflammatory bowel disease (IBD) each year, both in the United Kingdom and worldwide. Most drugs in current use for the treatment of IBD target the im...
Funder: The Daphne Jackson Trust | Value: £83,167

Does Residual Beta Cell Function and Exercise Offer Synergistic Protection Against Hyperglycaemic Induced Circulating Vasoprotective Dysfunction in Type 1 Diabetes?

2021 - 2022
For people with T1D, exercise is beneficial, potentially reducing the progression of diabetes-related complications. Many people (up to 80%) with T1D still release small amounts of insulin together wi...
Funder: Diabetes Research & Wellness Foundation