The inflammatory bowel disease drug azathioprine induces autophagy via mTORC1 and the unfolded protein response sensor PERK
Journal Article
Hooper, K. M., Casanova, V., Kemp, S., Staines, K. A., Satsangi, J., Barlow, P. G., …Stevens, C. (2019)
The inflammatory bowel disease drug azathioprine induces autophagy via mTORC1 and the unfolded protein response sensor PERK. Inflammatory Bowel Diseases, 25(9), 1481-1496. https://doi.org/10.1093/ibd/izz039
Background Genetic studies have strongly linked autophagy to Crohn's disease (CD) and stimulating autophagy in CD patients may be therapeutically beneficial. The aim of this s...
Interactions Between Autophagy and the Unfolded Protein Response: Implications for Inflammatory Bowel Disease
Journal Article
Hooper, K. M., Barlow, P. G., Henderson, P., & Stevens, C. (2019)
Interactions Between Autophagy and the Unfolded Protein Response: Implications for Inflammatory Bowel Disease. Inflammatory Bowel Diseases, 25(4), 661-671. https://doi.org/10.1093/ibd/izy380
Inflammatory Bowel Disease (IBD), which includes Crohn's disease (CD) and ulcerative colitis, is characterised by chronic inflammation of the gastrointestinal tract. Aetiology...
Inflammatory Bowel Disease Drugs: A Focus on Autophagy
Journal Article
Hooper, K. M., Barlow, P. G., Stevens, C., & Henderson, P. (2017)
Inflammatory Bowel Disease Drugs: A Focus on Autophagy. Journal of Crohn's and Colitis, 11(1), 118-127. https://doi.org/10.1093/ecco-jcc/jjw127
Inflammatory bowel disease [IBD] is characterized by chronic inflammation of the gastrointestinal tract. Medications such as corticosteroids, thiopurines, immunomodulators and...
Reduced alveolar macrophage migration induced by acute ambient particle (PM10) exposure
Journal Article
Barlow, P. G., Brown, D. M., Donaldson, K., MacCallum, J., & Stone, V. (2008)
Reduced alveolar macrophage migration induced by acute ambient particle (PM10) exposure. Cell Biology and Toxicology, 24(3), 243-252. https://doi.org/10.1007/s10565-007-9033-y
Increased levels of particulate air pollution (PM10) have been implicated as a causal agent in pulmonary disease exacerbation and increased deaths from respiratory and cardiov...
Nanoparticle and metal interactions and their impact on lung toxicology
Conference Proceeding
Wilson, M. R., Barlow, P. G., Hutchison, G. R., Guy, K., Griffiths, A., Simpson, R. J., …Stone, V. (2004)
Nanoparticle and metal interactions and their impact on lung toxicology. In Proceedings of the Ninth Annual UK Review Meeting on Outdoor and Indoor Air Pollution Research, 48-50. ISBN 1 899110 88 7
No abstract available.
Pro-inflammatory interactions between particles, metals and lung cells
Conference Proceeding
Donaldson, K., Hibbs, L., Heal, M., Tran, C. L., Lightbody, J., Barlow, P. G., …Stone, V. (2003)
Pro-inflammatory interactions between particles, metals and lung cells. In Effects of Air Contaminants on the Respiratory Tract - Interpretations from Molecules to Meta Analysis, 245-258. ISBN 978-3-8167-6478-6
No abstract available.