Research Output
Sequence and functional expression of the GABAA receptor shows a ligand-gated receptor super-family
  Amino-acid sequences derived from complementary DMAs encoding the α- and β-subunits of the GAB A/ benzo diazepine receptor from bovine brain show homology with other ligand-gated receptor subunits, suggesting that there is a super-family of ion-channel-containing receptors. Co-expression of the in vitro-generated α-subunit and β-subunit RNAs in Xenopus oocytes produces a functional receptor and ion channel with the pharmacological properties characteristic of the GABAA receptor.

  • Type:

    Article

  • Date:

    16 July 1987

  • Publication Status:

    Published

  • Publisher

    Nature Publishing Group

  • DOI:

    10.1038/328221a0

  • Cross Ref:

    328221a0

  • ISSN:

    0028-0836

  • Library of Congress:

    QD415-436 Biochemistry

  • Dewey Decimal Classification:

    572 Biochemistry

Citation

Schofield, P. R., Darlison, M. G., Fujita, N., Burt, D. R., Stephenson, F. A., Rodriguez, H., …Barnard, E. A. (1987). Sequence and functional expression of the GABAA receptor shows a ligand-gated receptor super-family. Nature, 328(6127), 221-227. https://doi.org/10.1038/328221a0

Keywords

Amino-acid sequences, DMAs encoding, GAB A/ benzo diazepine receptor, functional receptor channel,

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