Research Output
Patient factors associated with SSRI dose for depression treatment in general practice: A primary care cross sectional study
Antidepressant prescribing continues to rise. Increased long-term prescribing and higher doses are contributing to current growth; however, patient factors associated with the use of higher doses remain unknown. This study’s aim was to investigate patient factors associated with selective serotonin re-uptake inhibitor (SSRI) prescribed daily dose for depression treatment in general practice.
A stratified sample of low to high prescribing practices were selected. Routine individual patient-level data were extracted one practice at a time: September 2009 to January 2011. Patients included were ≥18 years, and prescribed an SSRI for depression. Logistic regression analysis was undertaken to assess individual predictor variables on SSRI daily dose by standard therapeutic dose versus higher dose, as SSRIs demonstrate flat dose response curves for depression treatment. Predictor variables included: age, gender, deprivation, co-morbidity, smoking status, being prescribed the same SSRI for ≥2 years, and patients’ general practice. For a subgroup of patients a second sub-group analysis included long-term benzodiazepine and/or z-hypnotic (B&Z) as a predictor variable.
Inter-practice SSRI prescribing varied significantly; practice point prevalence ranged from 2.5% (94/3697) to 11.9% (359/3007) of the practice population ≥18 years old; median 7.3% (250/3421) (χ2 = 2277.2, df = 10, p

  • Type:


  • Date:

    24 December 2014

  • Publication Status:


  • DOI:


  • Cross Ref:


  • ISSN:


  • Library of Congress:

    RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry

  • Dewey Decimal Classification:

    616.8 Nervous & mental disorders

  • Funders:

    Chief Scientists Office


Johnson, C. F., Dougall, N. J., Williams, B., MacGillivray, S. A., Buchanan, A. I., & Hassett, R. D. (2014). Patient factors associated with SSRI dose for depression treatment in general practice: A primary care cross sectional study. BMC family practice, 15(210),



Family practice, chronic disease, depression, antidepressive agents, Benzodiazepines

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    © 2014 Johnson et al.; licensee BioMed Central. This is an Open Access article distributed under the terms of the Creative
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