Research Output
Nutrient-hormone interaction in the ovine liver: methionine supply selectively modulates growth hormone-induced IGF-I gene expression.
  This study tested the hypothesis that specific amino acids are responsible for modulating the insulin-like growth factor-I (IGF-I) response to growth hormone (GH) in ovine hepatocytes. Cells were grown in media of defined amino acid composition, based on physiological concentrations (P.C.) of amino acids in sheep plasma. Relative to culture in 5P.C., amino acid limitation to 0·2P.C. had inhibitory effects on IGF-I RNA expression, peptide release and p70 S6 kinase phosphorylation (P

  • Type:

    Article

  • Date:

    01 August 2002

  • Publication Status:

    Published

  • DOI:

    10.1677/joe.0.1740335

  • ISSN:

    0022-0795

Citation

Stubbs, A. K., Wheelhouse, N. M., Lomax, M. A., & Hazlerigg, D. G. (2002). Nutrient-hormone interaction in the ovine liver: methionine supply selectively modulates growth hormone-induced IGF-I gene expression. Journal of Endocrinology, 174(2), (335-341). doi:10.1677/joe.0.1740335. ISSN 0022-0795

Authors

Keywords

Ovine liver, animal biology, IGF-1 gene,

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