Research Output
Bendigoles A~C, New Steroids from Gordonia australis Acta 2299†
  Bendigoles A~C are the first secondary metabolites to be isolated from a member of the actinomycete genus Gordonia. They were detected in a culture filtrate extract of Gordonia australis Acta 2299 by HPLC-diode array analysis and characterized as new steroids by mass spectrometry and NMR experiments. Bendigole C show binding affinity to the human progesterone and A~C to androgen receptor but are inactive at mineralocorticoid and estrogen receptors. In in vitro transactivation studies bendigoles A and C showed moderate and weak androgenic activities.

  • Type:


  • Date:

    31 May 2008

  • Publication Status:


  • Publisher

    Nature Publishing Group

  • DOI:


  • Cross Ref:


  • Library of Congress:

    RM Therapeutics. Pharmacology

  • Dewey Decimal Classification:

    615 Pharmacology and therapeutics


Schneider, K., Graf, E., Irran, E., Nicholson, G., Stainsby, F. M., Goodfellow, M., …Fiedler, H. (2008). Bendigoles A~C, New Steroids from Gordonia australis Acta 2299†. Journal of antibiotics. 61(6), 356-364. doi:10.1038/ja.2008.50. ISSN 0021-8820



bendigole A, bendigole B, bendigole C, Gordonia, steroids, fermentation, isolation, structure elucidation

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