Remdesivir-ivermectin combination displays synergistic interaction with improved in vitro activity against SARS-CoV-2
Journal Article
Jeffreys, L. N., Pennington, S. H., Duggan, J., Caygill, C. H., Lopeman, R. C., Breen, A. F., …Biagini, G. A. (2022)
Remdesivir-ivermectin combination displays synergistic interaction with improved in vitro activity against SARS-CoV-2. International Journal of Antimicrobial Agents, 59(3), Article 106542. https://doi.org/10.1016/j.ijantimicag.2022.106542
A key element for the prevention and management of COVID-19 is the development of effective therapeutics. Drug combination strategies of repurposed drugs offer several advanta...
Measurement of the Intracellular Mycobacterium tuberculosis Drug Effect and Prediction of the Clinical Dose–Response Relationship Using Intracellular Pharmacodynamic Modeling (PDi)
Book Chapter
Donnellan, S., Martínez-Rodríguez, C., Aljayyoussi, G., & Biagini, G. A. (2021)
Measurement of the Intracellular Mycobacterium tuberculosis Drug Effect and Prediction of the Clinical Dose–Response Relationship Using Intracellular Pharmacodynamic Modeling (PDi). In C. Barreiro, & J. Barredo (Eds.), Antimicrobial Therapies: Methods and Protocols (393-408). New York: Humana Press. https://doi.org/10.1007/978-1-0716-1358-0
The human disease tuberculosis (TB) is the leading cause of death from a single infectious agent. A quarter of the world’s population is estimated to be latently infected. Dru...
Intracellular Pharmacodynamic Modeling Is Predictive of the Clinical Activity of Fluoroquinolones against Tuberculosis
Journal Article
Donnellan, S., Aljayyoussi, G., Moyo, E., Ardrey, A., Martinez-Rodriguez, C., Ward, S. A., & Biagini, G. A. (2020)
Intracellular Pharmacodynamic Modeling Is Predictive of the Clinical Activity of Fluoroquinolones against Tuberculosis. Antimicrobial Agents and Chemotherapy, 64(1), https://doi.org/10.1128/aac.00989-19
Clinical studies of new antitubercular drugs are costly and time-consuming. Owing to the extensive tuberculosis (TB) treatment periods, the ability to identify drug candidates...
Nanomedicines towards targeting intracellular Mtb for the treatment of tuberculosis
Journal Article
Donnellan, S., & Giardiello, M. (2019)
Nanomedicines towards targeting intracellular Mtb for the treatment of tuberculosis. Journal of Interdisciplinary Nanomedicine, 4(3), 76-85. https://doi.org/10.1002/jin2.61
Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), causes the most human deaths than any other diseases from a single infectious agent. Treatments are long and cos...
Intracellular PD Modelling (PDi) for the Prediction of Clinical Activity of Increased Rifampicin Dosing
Journal Article
Aljayyoussi, G., Donnellan, S., Ward, S. A., & Biagini, G. A. (2019)
Intracellular PD Modelling (PDi) for the Prediction of Clinical Activity of Increased Rifampicin Dosing. Pharmaceutics, 11(6), https://doi.org/10.3390/pharmaceutics11060278
Increasing rifampicin (RIF) dosages could significantly reduce tuberculosis (TB) treatment durations. Understanding the pharmacokinetic-pharmacodynamics (PK–PD) of increasing ...
Intracellular delivery of nano-formulated antituberculosis drugs enhances bactericidal activity
Journal Article
Donnellan, S., Stone, V., Johnston, H., Giardiello, M., Owen, A., Rannard, S., …Stevenson, K. (2017)
Intracellular delivery of nano-formulated antituberculosis drugs enhances bactericidal activity. Journal of Interdisciplinary Nanomedicine, 2(3), 146-156. https://doi.org/10.1002/jin2.27
Tuberculosis kills more people worldwide than any other infectious disease. Treatment requires multiple drug therapy administered over long periods (6–24 months). The emergenc...
Pharmacokinetic-Pharmacodynamic modelling of intracellular Mycobacterium tuberculosis growth and kill rates is predictive of clinical treatment duration
Journal Article
Aljayyoussi, G., Jenkins, V. A., Sharma, R., Ardrey, A., Donnellan, S., Ward, S. A., & Biagini, G. A. (2017)
Pharmacokinetic-Pharmacodynamic modelling of intracellular Mycobacterium tuberculosis growth and kill rates is predictive of clinical treatment duration. Scientific Reports, 7(1), https://doi.org/10.1038/s41598-017-00529-6
Tuberculosis (TB) treatment is long and complex, typically involving a combination of drugs taken for 6 months. Improved drug regimens to shorten and simplify treatment are ur...
A rapid screening assay for identifying mycobacteria targeted nanoparticle antibiotics
Journal Article
Donnellan, S., Tran, L., Johnston, H., McLuckie, J., Stevenson, K., & Stone, V. (2016)
A rapid screening assay for identifying mycobacteria targeted nanoparticle antibiotics. Nanotoxicology, 10(6), 761-769. https://doi.org/10.3109/17435390.2015.1124468
Antibiotic resistance is a serious problem. Nanotechnology offers enormous potential in medicine, yet there is limited knowledge regarding the toxicity of nanoparticles (NP) f...