The type III intermediate filament vimentin regulates organelle distribution and modulates autophagy
Journal Article
Biskou, O., Casanova, V., Hooper, K., Kemp, S., Wright, G. P., Satsangi, J., …Stevens, C. (2019)
The type III intermediate filament vimentin regulates organelle distribution and modulates autophagy. PLOS ONE, 14(1), https://doi.org/10.1371/journal.pone.0209665
The cytoskeletal protein vimentin plays a key role in positioning of organelles within the cytosol and has been linked to the regulation of numerous cellular processes includi...
MS TCR Therapy
Patent
Wright, G., Stauss, H., & McGovern, J. MS TCR Therapy. United Kingdon)
Wright, G., Stauss, H., & McGovern, J. MS TCR Therapy. United Kingdon
Lower Resting and Exercise-Induced Circulating Angiogenic Progenitors and Angiogenic T-Cells in Older Men
Journal Article
Ross, M. D., Malone, E. M., Simpson, R., Cranston, I., Ingram, L., Wright, G. P., …Florida-James, G. D. (2018)
Lower Resting and Exercise-Induced Circulating Angiogenic Progenitors and Angiogenic T-Cells in Older Men. American journal of physiology. Heart and circulatory physiology, 314(3), 392-402. https://doi.org/10.1152/ajpheart.00592.2017
Ageing is associated with a dysfunctional endothelial phenotype, as well as reduced angiogenic capabilities. Exercise exerts beneficial effects on the cardiovascular system, p...
Engineering Specificity and Function of Therapeutic Regulatory T Cells
Journal Article
McGovern, J. L., Wright, G. P., & Stauss, H. J. (2017)
Engineering Specificity and Function of Therapeutic Regulatory T Cells. Frontiers in Immunology, 8, https://doi.org/10.3389/fimmu.2017.01517
Adoptive therapy with polyclonal regulatory T cells (Tregs) has shown efficacy in suppressing detrimental immune responses in experimental models of autoimmunity and transplan...
Remote ischaemic preconditioning in orthotopic liver transplantation (RIPCOLT trial): a pilot randomized controlled feasibility study
Journal Article
Robertson, F. P., Goswami, R., Wright, G. P., Imber, C., Sharma, D., Malago, M., …Davidson, B. R. (2017)
Remote ischaemic preconditioning in orthotopic liver transplantation (RIPCOLT trial): a pilot randomized controlled feasibility study. HPB, 19(9), 757-767. https://doi.org/10.1016/j.hpb.2017.05.005
Background
Ischaemia Reperfusion (IR) injury is a major cause of morbidity, mortality and graft loss following Orthotopic Liver Transplantation (OLT). Utilising marginal graft...
Recruitment of inflammatory monocytes after liver transplantation and correlation with clinical outcome
Presentation / Conference
Robertson, F., Male, V., Wright, G., Fuller, B., & Davidson, B. (2017, February)
Recruitment of inflammatory monocytes after liver transplantation and correlation with clinical outcome
Background
Ischaemia reperfusion injury is a key cause of mortality and graft loss after liver transplantation. After tissue injury, monocytes are rapidly mobilised and recrui...
A systematic review and meta-analysis of donor ischaemic preconditioning in liver transplantation
Journal Article
Robertson, F. P., Magill, L. J., Wright, G. P., Fuller, B., & Davidson, B. R. (2016)
A systematic review and meta-analysis of donor ischaemic preconditioning in liver transplantation. Transplant International, 29(11), 1147-1154. https://doi.org/10.1111/tri.12849
Ischaemic preconditioning (IPC) is a strategy to reduce ischaemia–reperfusion (IR) injury. Its benefit in human liver transplantation is unclear. The aim of this study was to ...
Protocol for a prospective randomized controlled trial of recipient remote ischaemic preconditioning in orthotopic liver transplantation (RIPCOLT trial)
Journal Article
Robertson, F. P., Goswami, R., Wright, G. P., Fuller, B., & Davidson, B. R. (2016)
Protocol for a prospective randomized controlled trial of recipient remote ischaemic preconditioning in orthotopic liver transplantation (RIPCOLT trial). Transplantation Research, 5(1), https://doi.org/10.1186/s13737-016-0033-4
Ischaemic reperfusion (IR) injury is a major cause of graft loss, morbidity and mortality following orthotopic liver transplantation (OLT). Demand for liver transplantation ha...
Human MHC Class I-restricted high avidity CD4 + T cells generated by co-transfer of TCR and CD8 mediate efficient tumor rejection in vivo
Journal Article
Xue, S., Gao, L., Ahmadi, M., Ghorashian, S., Barros, R. D., Pospori, C., …Stauss, H. J. (2013)
Human MHC Class I-restricted high avidity CD4 + T cells generated by co-transfer of TCR and CD8 mediate efficient tumor rejection in vivo. OncoImmunology, 2(1), https://doi.org/10.4161/onci.22590
In this study, we generated human MHC Class I-restricted CD4+ T cells specific for Epstein-Barr virus (EBV) and cytomegalovirus (CMV), two herpesviridae associated with lympho...
CD3 limits the efficacy of TCR gene therapy in vivo
Journal Article
Ahmadi, M., King, J. W., Xue, S. A., Voisine, C., Holler, A., Wright, G. P., …Stauss, H. J. (2011)
CD3 limits the efficacy of TCR gene therapy in vivo. Blood, 118(13), 3528-3537. https://doi.org/10.1182/blood-2011-04-346338
The function of T-cell receptor (TCR) gene modified T cells is dependent on efficient surface expression of the introduced TCR / heterodimer. We tested whether endogenous CD3...