Conditional deletion of E11/podoplanin in bone protects against load-induced osteoarthritis
Journal Article
Staines, K., Ikpegbu, E., Törnqvist, A., Dillon, S., Javaheri, B., Amin, A. K., …Farquharson, C. (2019)
Conditional deletion of E11/podoplanin in bone protects against load-induced osteoarthritis. BMC Musculoskeletal Disorders, 20, https://doi.org/10.1186/s12891-019-2731-9
Background: Subchondral bone (SCB) thickening is one of the earliest detectable changes in osteoarthritic joints and is considered a potential trigger for subsequent articular...
The inflammatory bowel disease drug azathioprine induces autophagy via mTORC1 and the unfolded protein response sensor PERK
Journal Article
Hooper, K. M., Casanova, V., Kemp, S., Staines, K. A., Satsangi, J., Barlow, P. G., …Stevens, C. (2019)
The inflammatory bowel disease drug azathioprine induces autophagy via mTORC1 and the unfolded protein response sensor PERK. Inflammatory Bowel Diseases, 25(9), 1481-1496. https://doi.org/10.1093/ibd/izz039
Background Genetic studies have strongly linked autophagy to Crohn's disease (CD) and stimulating autophagy in CD patients may be therapeutically beneficial. The aim of this s...
Interactions Between Autophagy and the Unfolded Protein Response: Implications for Inflammatory Bowel Disease
Journal Article
Hooper, K. M., Barlow, P. G., Henderson, P., & Stevens, C. (2019)
Interactions Between Autophagy and the Unfolded Protein Response: Implications for Inflammatory Bowel Disease. Inflammatory Bowel Diseases, 25(4), 661-671. https://doi.org/10.1093/ibd/izy380
Inflammatory Bowel Disease (IBD), which includes Crohn's disease (CD) and ulcerative colitis, is characterised by chronic inflammation of the gastrointestinal tract. Aetiology...
The role of social context in symptom appraisal and help-seeking among people with lung or colorectal symptoms: A qualitative interview study
Journal Article
Dobson, C., Russell, A., Brown, S., & Rubin, G. (2018)
The role of social context in symptom appraisal and help-seeking among people with lung or colorectal symptoms: A qualitative interview study. European Journal of Cancer Care, 27(2), https://doi.org/10.1111/ecc.12815
Prolonged diagnostic intervals are associated with poorer outcomes, and the patient interval appears to be a substantial contributor to the overall length of the diagnostic in...
Control of Antimicrobial Resistance Requires an Ethical Approach
Journal Article
Parsonage, B., Hagglund, P. K., Keogh, L., Wheelhouse, N., Brown, R. E., & Dancer, S. J. (2017)
Control of Antimicrobial Resistance Requires an Ethical Approach. Frontiers in Microbiology, 8, https://doi.org/10.3389/fmicb.2017.02124
Ethical behavior encompasses actions that benefit both self and society. This means that tackling antimicrobial resistance (AMR) becomes an ethical obligation, because the pro...
Preferential activation of HIF-2α adaptive signalling in neuronal-like cells in response to acute hypoxia
Journal Article
Martín-Aragón Baudel, M. A. S., Rae, M. T., Darlison, M. G., Poole, A. V., & Fraser, J. A. (2017)
Preferential activation of HIF-2α adaptive signalling in neuronal-like cells in response to acute hypoxia. PLOS ONE, 12(10), https://doi.org/10.1371/journal.pone.0185664
Stroke causes severe neuronal damage as disrupted cerebral blood flow starves neurons of oxygen and glucose. The hypoxia inducible factors (HIF-1α and HIF-2α) orchestrate oxyg...
Inflammatory Bowel Disease Drugs: A Focus on Autophagy
Journal Article
Hooper, K. M., Barlow, P. G., Stevens, C., & Henderson, P. (2017)
Inflammatory Bowel Disease Drugs: A Focus on Autophagy. Journal of Crohn's and Colitis, 11(1), 118-127. https://doi.org/10.1093/ecco-jcc/jjw127
Inflammatory bowel disease [IBD] is characterized by chronic inflammation of the gastrointestinal tract. Medications such as corticosteroids, thiopurines, immunomodulators and...
Health value & perceived control over health: behavioural constructs to support Type 2 diabetes self-management in clinical practice
Journal Article
Nugent, L. E., Carson, M., Zammitt, N. N., Smith, G. D., & Wallston, K. A. (2015)
Health value & perceived control over health: behavioural constructs to support Type 2 diabetes self-management in clinical practice. Journal of Clinical Nursing, 24(15-16), 2201-2210. https://doi.org/10.1111/jocn.12878
Aims and objectives
To explore health value and perceived control over health in relation to self-management behaviours in adults with Type 2 diabetes mellitus.
Background
H...
Effects of etidronate on the Enpp1−/− mouse model of generalized arterial calcification of infancy
Journal Article
Huesa, C., Staines, K. A., Millán, J. L., & MacRae, V. E. (2015)
Effects of etidronate on the Enpp1−/− mouse model of generalized arterial calcification of infancy. International Journal of Molecular Medicine, 36(1), 159-165. https://doi.org/10.3892/ijmm.2015.2212
Generalized arterial calcification of infancy (GACI) is an autosomal recessive disorder of spontaneous infantile arterial and periarticular calcification which is attributed t...
PWE-090 the effect of commonly used Ibd drugs on autophagy induction using an in vitro cell culture system.
Journal Article
Henderson, P., Satsangi, J., Wilson, D., & Stevens, C. (2014)
PWE-090 the effect of commonly used Ibd drugs on autophagy induction using an in vitro cell culture system. Gut, 63(Suppl 1), A163. https://doi.org/10.1136/gutjnl-2014-307263.350
Introduction Genome wide association studies and functional experiments in inflammatory bowel disease (IBD) have delineated the importance of autophagy in IBD pathogenesis. We...