Carbon Nanoparticles Inhibit the Antimicrobial Activities of the Human Cathelicidin LL-37 through Structural Alteration
Journal Article
Findlay, F., Pohl, J., Svoboda, P., Shakamuri, P., McLean, K., Inglis, N. F., …Barlow, P. G. (2017)
Carbon Nanoparticles Inhibit the Antimicrobial Activities of the Human Cathelicidin LL-37 through Structural Alteration. Journal of Immunology, 199(7), 2483-2490. https://doi.org/10.4049/jimmunol.1700706
Host defense peptides, also known as antimicrobial peptides, are key elements of innate host defense. One host defense peptide with well-characterized antimicrobial activity i...
Cathelicidins display conserved direct antiviral activity towards rhinovirus.
Journal Article
Sousa, F. H., Casanova, V., Findlay, F., Stevens, C., Svoboda, P., Pohl, J., …Barlow, P. G. (2017)
Cathelicidins display conserved direct antiviral activity towards rhinovirus. Peptides, 95, 76-83. https://doi.org/10.1016/j.peptides.2017.07.013
Human rhinoviruses (HRVs) are the most common cause of viral respiratory tract infections, and are associated with significant morbidity and mortality in immunocompromised ind...
Development of mitochondria- and protease-specific prodrugs in the potential treatment of parasitic helminth infections
Presentation / Conference
Oluwadare, E., Rehan, A., Ding, Y., Turnbull, A., Malone, E., Mincher, D., & Proudfoot, L. (2016, September)
Development of mitochondria- and protease-specific prodrugs in the potential treatment of parasitic helminth infections. Poster presented at Molecular & Cellular Biology of Helminth Parasites X, Hydra, Greece
Anthelmintic resistance and the shortage of new drugs represent an urgent need for the development of novel anti-parasite drugs with effective delivery to the target site. Red...
Cationic host defense peptides; novel antimicrobial therapeutics against Category A pathogens and emerging infections
Journal Article
Findlay, F., Proudfoot, L., Stevens, C., & Barlow, P. G. (2016)
Cationic host defense peptides; novel antimicrobial therapeutics against Category A pathogens and emerging infections. Pathogens and Global Health, 110(4-5), 137-147. https://doi.org/10.1080/20477724.2016.1195036
Cationic Host Defense Peptides (HDP, also known as antimicrobial peptides) are crucial components of the innate immune system and possess broad-spectrum antibacterial, antivir...
The assessment of a protease -dependent prodrug in the nematode Caenorhabditis elegans for the treatment of parasitic helminth infections
Presentation / Conference Contribution
Oluwadare, E., Turnbull, A., Malone, E., Mincher, D., & Proudfoot, L. (2015, August)
The assessment of a protease -dependent prodrug in the nematode Caenorhabditis elegans for the treatment of parasitic helminth infections. Poster presented at Molecular & Cellular Biology of Helminth Parasites IX, Hydra, Greece
Billions of livestock, and a third of the current human population, are infected with helminth parasites. In livestock, these helminth infections are accompanied by significan...
Multi-walled carbon nanotube induced frustrated phagocytosis, cytotoxicity and pro-inflammatory conditions in macrophages are length dependent and greater than that of asbestos
Journal Article
Boyles, M. S., Young, L., Brown, D. M., MacCalman, L., Cowie, H., Moisala, A., …Stone, V. (2015)
Multi-walled carbon nanotube induced frustrated phagocytosis, cytotoxicity and pro-inflammatory conditions in macrophages are length dependent and greater than that of asbestos. Toxicology in Vitro, 29(7), 1513-1528. https://doi.org/10.1016/j.tiv.2015.06.012
The potential toxicity of carbon nanotubes (CNTs) has been compared to pathogenic fibres such as asbestos. It is important to test this hypothesis to ascertain safe methods fo...
Driving Forward a Programme Based Approach - A Skills Passport Project
Presentation / Conference
Klawitter, P., Proudfoot, L., Mackinnon, J., Briers, R., Taylor, C., & Campbell Casey, S. (2013, June)
Driving Forward a Programme Based Approach - A Skills Passport Project. Poster presented at Edinburgh Napier University Staff Conference, Edinburgh
Zinc oxide nanoparticles and monocytes: Impact of size, charge and solubility on activation status
Journal Article
Prach, M., Stone, V., & Proudfoot, L. (2012)
Zinc oxide nanoparticles and monocytes: Impact of size, charge and solubility on activation status. Toxicology and Applied Pharmacology, 266(1), 19-26. https://doi.org/10.1016/j.taap.2012.10.020
Zinc oxide (ZnO) particle induced cytotoxicity was dependent on size, charge and solubility, factors which at sublethal concentrations may influence the activation of the huma...
Role of EGFR in intestinal barrier function in response to challenges with silver nanoparticles and enteric pathogens
Presentation / Conference Contribution
Sehgal, A., Hutchison, G., Proudfoot, L., Malone, E., Cameron, P., & Fraser-Pitt, D. (2012, July)
Role of EGFR in intestinal barrier function in response to challenges with silver nanoparticles and enteric pathogens. Poster presented at Society for Applied Microbiology Summer Conference: Resistance, Adaptation and Bioremediation, Edinburgh
Caenorhabditis elegans as a Model for the Assessment of Nanomaterial Toxicity
Presentation / Conference Contribution
Nicol, L., Malone, E., & Proudfoot, L. (2012, April)
Caenorhabditis elegans as a Model for the Assessment of Nanomaterial Toxicity. Poster presented at British Society for Parasitology Conference, 50th Anniversary, Glasgow
Nanomaterials, having at least one dimension less than 100nm, have unique physico-chemical properties due to their small size, large surface area and surface reactivity. Manuf...