Morphological and mechanical characterisation of the hindwing nodus from the Libellulidae family of dragonfly (Indonesia)
Journal Article
Fauziyah, S., Alam, C., Soesilohadi, R., Retnoaji, B., & Alam, P. (2014)
Morphological and mechanical characterisation of the hindwing nodus from the Libellulidae family of dragonfly (Indonesia). Arthropod Structure and Development, 43(5), 415-422. https://doi.org/10.1016/j.asd.2014.06.004
In this communication, the morphologies and mechanical characteristics of nodi from the hindwings of seven Indonesian Libellulidae dragonfly species are identified. Geometrica...
In vivo imaging of reactive oxygen and nitrogen species in murine colitis
Journal Article
Asghar, M. N., Emani, R., Alam, C., Helenius, T. O., Grönroos, T. J., Sareila, O., …Toivola, D. M. (2014)
In vivo imaging of reactive oxygen and nitrogen species in murine colitis. Inflammatory Bowel Diseases, 20(8), 1435-1447. https://doi.org/10.1097/mib.0000000000000118
Traditional techniques analyzing mouse colitis are invasive, laborious, or indirect. Development of in vivo imaging techniques for specific colitis processes would be useful f...
On the non-linear attachment characteristics of blood to bacterial cellulose/kaolin biomaterials
Journal Article
Véliz, D. S., Alam, C., Toivola, D. M., Toivakka, M., & Alam, P. (2014)
On the non-linear attachment characteristics of blood to bacterial cellulose/kaolin biomaterials. Colloids and Surfaces B: Biointerfaces, 116, 176-182. https://doi.org/10.1016/j.colsurfb.2013.12.038
In this communication, we report a non-linear variation in the strength of blood attachment to bacterial cellulose/kaolin biomaterials as the fractions of bacterial cellulose ...
Keratin 8 modulates β-cell stress responses and normoglycaemia
Journal Article
Alam, C. M., Silvander, J. S., Daniel, E. N., Tao, G., Kvarnström, S. M., Alam, P., …Toivola, D. M. (2013)
Keratin 8 modulates β-cell stress responses and normoglycaemia. Journal of Cell Science, 126(24), 5635-5644. https://doi.org/10.1242/jcs.132795
Keratin intermediate filament (IF) proteins are epithelial cell cytoskeletal components that provide structural stability and protection from cell stress, among other cellular...
Effects of a germ-free environment on gut immune regulation and diabetes progression in non-obese diabetic (NOD) mice
Journal Article
Alam, C., Bittoun, E., Bhagwat, D., Valkonen, S., Saari, A., Jaakkola, U., …Hänninen, A. (2011)
Effects of a germ-free environment on gut immune regulation and diabetes progression in non-obese diabetic (NOD) mice. Diabetologia, 54, 1398-1406. https://doi.org/10.1007/s00125-011-2097-5
Aims/hypothesis
Microbial factors influence the development of diabetes in NOD mice. Studies in germ-free animals have revealed important roles of microbiota in the regulation...
Ly6C supports preferential homing of central memory CD8+ T cells into lymph nodes
Journal Article
Hänninen, A., Maksimow, M., Alam, C., Morgan, D. J., & Jalkanen, S. (2011)
Ly6C supports preferential homing of central memory CD8+ T cells into lymph nodes. European Journal of Immunology, 41(3), 634-644. https://doi.org/10.1002/eji.201040760
Ly6C is a murine cell-surface antigen expressed by plasma cells, subsets of myeloid cells and many T cells, including memory T cells. We previously documented that Ly6C crossl...
Inflammatory tendencies and overproduction of IL-17 in the colon of young NOD mice are counteracted with diet change
Journal Article
Alam, C., Valkonen, S., Palagani, V., Jalava, J., Eerola, E., & Hänninen, A. (2010)
Inflammatory tendencies and overproduction of IL-17 in the colon of young NOD mice are counteracted with diet change. Diabetes, 59(9), 2237—2246. https://doi.org/10.2337/db10-0147
Objective
Dietary factors influence diabetes development in the NOD mouse. Diet affects the composition of microbiota in the distal intestine, which may subsequently influence...
Enhanced trafficking to the pancreatic lymph nodes and auto-antigen presentation capacity distinguishes peritoneal B lymphocytes in non-obese diabetic mice
Journal Article
Alam, C., Valkonen, S., Ohls, S., Törnqvist, K., & Hänninen, A. (2010)
Enhanced trafficking to the pancreatic lymph nodes and auto-antigen presentation capacity distinguishes peritoneal B lymphocytes in non-obese diabetic mice. Diabetologia, 53, 346-355. https://doi.org/10.1007/s00125-009-1599-x
<h4>Aims/hypothesis</h4>NOD.Igmicro ( null ) mice lacking mature B cells are highly resistant to diabetes and display poor CD4 T cell responses to autoantigens. Ne...
Sphingosine kinase as an oncogene: autocrine sphingosine 1-phosphate modulates ML-1 thyroid carcinoma cell migration by a mechanism dependent on protein kinase C-alpha and ERK1/2
Journal Article
Bergelin, N., Blom, T., Heikkilä, J., Löf, C., Alam, C., Balthasar, S., …Törnquist, K. (2009)
Sphingosine kinase as an oncogene: autocrine sphingosine 1-phosphate modulates ML-1 thyroid carcinoma cell migration by a mechanism dependent on protein kinase C-alpha and ERK1/2. Endocrinology, 150(5), 2055-2063. https://doi.org/10.1210/en.2008-0625
Sphingosine 1-phosphate (S1P) induces migration of the human thyroid follicular carcinoma cell line ML-1 by activation of S1P(1) and S1P(3) receptors, G(i) proteins, and the p...
Incomplete Killing And Enhanced Activation of Islet-Reactive CD8+ T Cells by FasL-Expressing Dendritic Cells Limits Protection from Diabetes
Journal Article
Maksimow, M., Alam, C., & Hänninen, A. (2008)
Incomplete Killing And Enhanced Activation of Islet-Reactive CD8+ T Cells by FasL-Expressing Dendritic Cells Limits Protection from Diabetes. The Review of Diabetic Studies, 5(3), 144-153. https://doi.org/10.1900/rds.2008.5.144
AIMS: Autologous dendritic cells (DC) are a promising tool for induction of cytotoxic CD8+ T cell immunity against tumors and chronic viral infections. When armed with the dea...