Creating connections: developing an online space for cross-regional mentorship and network building in the dementia research field
Journal Article
Fullerton, J., Bettencourt, C., Daniels, M., Mclean, F., Simpson, S., Smith, A., …Kerr, F. (2022)
Creating connections: developing an online space for cross-regional mentorship and network building in the dementia research field. AMRC Open Research, 4, Article 22. https://doi.org/10.12688/amrcopenres.13091.1
Background
Effective development and retention of talented early-career researchers (ECRs) is essential to the continued success of biomedical science research fields. To this...
Building a Systematic Online Living Evidence Summary of COVID-19 Research
Journal Article
Hair, K., Sena, E. S., Wilson, E., Currie, G., Macleod, M., Bahor, Z., …Drury, B. (in press)
Building a Systematic Online Living Evidence Summary of COVID-19 Research. Journal of the European Association for Health Information and Libraries, 17(2), 21-26. https://doi.org/10.32384/jeahil17465
Throughout the global coronavirus pandemic, we have seen an unprecedented volume of COVID-19 researchpublications. This vast body of evidence continues to grow, making it diff...
Activating transcription factor 4-dependent lactate dehydrogenase activation as a protective response to amyloid beta toxicity
Journal Article
Niccoli, T., Kerr, F., Snoeren, I., Fabian, D., Aleyakpo, B., Ivanov, D., …Partridge, L. (2021)
Activating transcription factor 4-dependent lactate dehydrogenase activation as a protective response to amyloid beta toxicity. Brain Communications, 3(2), https://doi.org/10.1093/braincomms/fcab053
Accumulation of amyloid beta peptides is thought to initiate the pathogenesis of Alzheimer’s disease. However, the precise mechanisms mediating their neurotoxicity are unclear...
Dynamic changes in the brain protein interaction network correlates with progression of Aβ42 pathology in Drosophila
Journal Article
Scholes, H. M., Cryar, A., Kerr, F., Sutherland, D., Gethings, L. A., Vissers, J. P. C., …Thalassinos, K. (2020)
Dynamic changes in the brain protein interaction network correlates with progression of Aβ42 pathology in Drosophila. Scientific Reports, 10(1), https://doi.org/10.1038/s41598-020-74748-9
Alzheimer’s disease (AD), the most prevalent form of dementia, is a progressive and devastating neurodegenerative condition for which there are no effective treatments. Unders...
Molecular Mechanisms of Lithium Action: Switching the Light on Multiple Targets for Dementia Using Animal Models
Journal Article
Kerr, F., Bjedov, I., & Sofola-Adesakin, O. (2018)
Molecular Mechanisms of Lithium Action: Switching the Light on Multiple Targets for Dementia Using Animal Models. Frontiers in Molecular Neuroscience, 11, https://doi.org/10.3389/fnmol.2018.00297
Lithium has long been used for the treatment of psychiatric disorders, due to its robust beneficial effect as a mood stabilizing drug. Lithium’s effectiveness for improving ne...
Direct Keap1-Nrf2 disruption as a potential therapeutic target for Alzheimer’s disease
Journal Article
Kerr, F., Sofola-Adesakin, O., Ivanov, D. K., Gatliff, J., Gomez Perez-Nievas, B., Bertrand, H. C., …Partridge, L. (2017)
Direct Keap1-Nrf2 disruption as a potential therapeutic target for Alzheimer’s disease. PLoS Genetics, 13(3), https://doi.org/10.1371/journal.pgen.1006593
Nrf2, a transcriptional activator of cell protection genes, is an attractive therapeutic target for the prevention of neurodegenerative diseases, including Alzheimer’s disease...
Increased Glucose Transport into Neurons Rescues Aβ Toxicity in Drosophila
Journal Article
Niccoli, T., Cabecinha, M., Tillmann, A., Kerr, F., Wong, C., Cardenes, D., …Partridge, L. (2016)
Increased Glucose Transport into Neurons Rescues Aβ Toxicity in Drosophila. Current Biology, 26(17), 2291-2300. https://doi.org/10.1016/j.cub.2016.07.017
Glucose hypometabolism is a prominent feature of the brains of patients with Alzheimer's disease (AD). Disease progression is associated with a reduction in glucose transporte...
Lithium Promotes Longevity through GSK3/NRF2-Dependent Hormesis
Journal Article
Castillo-Quan, J., Li, L., Kinghorn, K., Ivanov, D., Tain, L., Slack, C., …Partridge, L. (2016)
Lithium Promotes Longevity through GSK3/NRF2-Dependent Hormesis. Cell Reports, 15(3), 638-650. https://doi.org/10.1016/j.celrep.2016.03.041
The quest to extend healthspan via pharmacological means is becoming increasingly urgent, both from a health and economic perspective. Here we show that lithium, a drug approv...
Deletion of endogenous Tau proteins is not detrimental in Drosophila
Journal Article
Burnouf, S., Grönke, S., Augustin, H., Dols, J., Gorsky, M. K., Werner, J., …Partridge, L. (2016)
Deletion of endogenous Tau proteins is not detrimental in Drosophila. Scientific Reports, 6, https://doi.org/10.1038/srep23102
Human Tau (hTau) is a highly soluble and natively unfolded protein that binds to microtubules within neurons. Its dysfunction and aggregation into insoluble paired helical fil...
A holidic medium for Drosophila melanogaster
Journal Article
Piper, M. D. W., Blanc, E., Leitão-Gonçalves, R., Yang, M., He, X., Linford, N. J., …Partridge, L. (2014)
A holidic medium for Drosophila melanogaster. Nature methods, 11(1), 100-105. https://doi.org/10.1038/nmeth.2731
A critical requirement for research using model organisms is a well-defined and consistent diet. There is currently no complete chemically defined (holidic) diet available for...