Carbon Nanoparticles Inhibit the Antimicrobial Activities of the Human Cathelicidin LL-37 through Structural Alteration
Journal Article
Findlay, F., Pohl, J., Svoboda, P., Shakamuri, P., McLean, K., Inglis, N. F., …Barlow, P. G. (2017)
Carbon Nanoparticles Inhibit the Antimicrobial Activities of the Human Cathelicidin LL-37 through Structural Alteration. Journal of Immunology, 199(7), 2483-2490. https://doi.org/10.4049/jimmunol.1700706
Host defense peptides, also known as antimicrobial peptides, are key elements of innate host defense. One host defense peptide with well-characterized antimicrobial activity i...
Cathelicidins display conserved direct antiviral activity towards rhinovirus.
Journal Article
Sousa, F. H., Casanova, V., Findlay, F., Stevens, C., Svoboda, P., Pohl, J., …Barlow, P. G. (2017)
Cathelicidins display conserved direct antiviral activity towards rhinovirus. Peptides, 95, 76-83. https://doi.org/10.1016/j.peptides.2017.07.013
Human rhinoviruses (HRVs) are the most common cause of viral respiratory tract infections, and are associated with significant morbidity and mortality in immunocompromised ind...
Zinc oxide nanoparticles and monocytes: Impact of size, charge and solubility on activation status
Journal Article
Prach, M., Stone, V., & Proudfoot, L. (2012)
Zinc oxide nanoparticles and monocytes: Impact of size, charge and solubility on activation status. Toxicology and Applied Pharmacology, 266(1), 19-26. https://doi.org/10.1016/j.taap.2012.10.020
Zinc oxide (ZnO) particle induced cytotoxicity was dependent on size, charge and solubility, factors which at sublethal concentrations may influence the activation of the huma...
Parasitic helminths tip the balance: potential anti-inflammatory therapies
Journal Article
Proudfoot, L. (2004)
Parasitic helminths tip the balance: potential anti-inflammatory therapies. Immunology, 113(4), 438-440. https://doi.org/10.1111/j.1365-2567.2004.01996.x
Parasitic helminths are worms that are classified within the phyla Nematoda (roundworms) and Platyhelminthes (flatworms) (see Table 1). Some nematode species, Filariae being a...
Biosynthesis of the glycolipid anchor of lipophosphoglycan and the structurally related glycoinositolphospholipids from Leishmania major
Journal Article
Proudfoot, L., Schneider, P., Ferguson, M. A. J., & McConville, M. J. (1995)
Biosynthesis of the glycolipid anchor of lipophosphoglycan and the structurally related glycoinositolphospholipids from Leishmania major. The biochemical journal, 308(1), 45-55. https://doi.org/10.1042/bj3080045
The major macromolecule on the surface of the protozoan parasite Leishmania major is a lipophosphoglycan (LPG) which contains a glycosylphosphatidylinositol glycolipid anchor....
External stimuli and intracellular signalling in the modification of the nematode surface during transition to the mammalian host environment
Journal Article
Proudfoot, L., Kusel, J. R., Smith, H. V., & Kennedy, M. W. (1993)
External stimuli and intracellular signalling in the modification of the nematode surface during transition to the mammalian host environment. Parasitology, 107(05), 559. https://doi.org/10.1017/s0031182000068141
Previous work has shown that the surface of infective larvae of parasitic nematodes will not bind the fluorescent lipid analogue 5-N(octadecanoyl)aminofluorescein (AF18) until...
Rapid changes in the surface of parasitic nematodes during transition from pre- to post-parasitic forms
Journal Article
Proudfoot, L., Kusel, J. R., Smith, H. V., Harnett, W., Worms, M. J., & Kennedy, M. W. (1993)
Rapid changes in the surface of parasitic nematodes during transition from pre- to post-parasitic forms. Parasitology, 107(01), 107. doi:10.1017/s0031182000079464
All mammalian-parasitic stages of a range of nematode species investigated (Brugia pahangi, Acanthocheilonema viteae, Strongyloides ratti, Nippostrongylus brasiliensis, Trichi...
The surface lipid of parasitic nematodes: Organization, and modifications during transition to the mammalian host environment
Journal Article
Proudfoot, L., Kusel, J. R., Smith, H. V., Harnett, W., Worms, M. J., & Kennedy, M. W. (1990)
The surface lipid of parasitic nematodes: Organization, and modifications during transition to the mammalian host environment. Acta tropica, 47(5-6), 323-330. https://doi.org/10.1016/0001-706x%2890%2990033-v
The biophysical properties of the surface lipid of a range of nematode species and their developmental stages were examined, using fluorescent lipid probes and fluorescence re...