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11 results

In vivo in uterus non-invasive methods to predict placental insufficiency and adverse pregnancy outcomes in antiphospholipid syndrome

Conference Proceeding
Girardi, G., Fraser, J., Bertolaccini, M. L., Lennen, R., Vontell, R., & Hutchison, G. (2014)
In vivo in uterus non-invasive methods to predict placental insufficiency and adverse pregnancy outcomes in antiphospholipid syndrome. https://doi.org/10.1016/j.placenta.2014.06.184
Objectives: To use MRI-based methods to non invasively detect placental insufficiency and predict fetal outcomes in obstetric antiphospholipid syndrome (APS) Methods and resul...

Androgen action in the masculinization programming window and development of male reproductive organs

Journal Article
MacLeod, D. J., Sharpe, R. M., Welsh, M., Fisken, M., Scott, H. M., Hutchison, G. R., …van den Driesche, S. (2010)
Androgen action in the masculinization programming window and development of male reproductive organs. International Journal of Andrology, 33(2), 279-287. https://doi.org/10.1111/j.1365-2605.2009.01005.x
We have shown previously that deficient androgen action within a masculinization programming window (MPW; e15.5–e18.5 in rats) is important in the origin of male reproductive ...

A review of the in vivo and in vitro toxicity of silver and gold particulates: Particle attributes and biological mechanisms responsible for the observed toxicity

Journal Article
Johnston, H. J., Hutchison, G., Christensen, F. M., Peters, S., Hankin, S., & Stone, V. (2010)
A review of the in vivo and in vitro toxicity of silver and gold particulates: Particle attributes and biological mechanisms responsible for the observed toxicity. Critical Reviews in Toxicology, 40(4), 328-346. https://doi.org/10.3109/10408440903453074
This review is concerned with evaluating the toxicity associated with human exposure to silver and gold nanoparticles (NPs), due to the relative abundance of toxicity data ava...

A critical review of the biological mechanisms underlying the in vivo and in vitro toxicity of carbon nanotubes: The contribution of physico-chemical characteristics

Journal Article
Johnston, H. J., Hutchison, G. R., Christensen, F. M., Peters, S., Hankin, S., Aschberger, K., & Stone, V. (2010)
A critical review of the biological mechanisms underlying the in vivo and in vitro toxicity of carbon nanotubes: The contribution of physico-chemical characteristics. Nanotoxicology, 4(2), 207-246. https://doi.org/10.3109/17435390903569639
This critical review of the available human health safety data, relating to carbon nanotubes (CNTs), was conducted in order to assess the risks associated with CNT exposure. D...

Identification of the mechanisms that drive the toxicity of TiO2 particulates: the contribution of physicochemical characteristics

Journal Article
Johnston, H. J., Hutchison, G. R., Christensen, F. M., Peters, S., Hankin, S., & Stone, V. (2009)
Identification of the mechanisms that drive the toxicity of TiO2 particulates: the contribution of physicochemical characteristics. Particle and fibre toxicology, 6(1), 33. https://doi.org/10.1186/1743-8977-6-33
This review focuses on outlining the toxicity of titanium dioxide (TiO₂) particulates in vitro and in vivo, in order to understand their ability to detrimentally impact...

Glucocorticoids Amplify Dibutyl Phthalate-Induced Disruption of Testosterone Production and Male Reproductive Development

Journal Article
Drake, A. J., van den Driesche, S., Scott, H. M., Hutchison, G. R., Seckl, J. R., & Sharpe, R. M. (2009)
Glucocorticoids Amplify Dibutyl Phthalate-Induced Disruption of Testosterone Production and Male Reproductive Development. Endocrinology, 150(11), 5055-5064. https://doi.org/10.1210/en.2009-0700
Common male reproductive abnormalities including cryptorchidism, hypospadias, and low sperm counts may comprise a testicular dysgenesis syndrome (TDS), resulting from fetal te...

The Biological Mechanisms and Physicochemical Characteristics Responsible for Driving Fullerene Toxicity

Journal Article
Johnston, H. J., Hutchison, G. R., Christensen, F. M., Aschberger, K., & Stone, V. (2010)
The Biological Mechanisms and Physicochemical Characteristics Responsible for Driving Fullerene Toxicity. Toxicological Sciences, 114(2), 162-182. https://doi.org/10.1093/toxsci/kfp265
This review provides a comprehensive critical review of the available literature purporting to assess the toxicity of carbon fullerenes. This is required as prior to the wides...

Sertoli Cell Development and Function in an Animal Model of Testicular Dysgenesis Syndrome1

Journal Article
Hutchison, G. R., Scott, H. M., Walker, M., McKinnell, C., Ferrara, D., Mahood, I. K., & Sharpe, R. M. (2008)
Sertoli Cell Development and Function in an Animal Model of Testicular Dysgenesis Syndrome1. Biology of Reproduction, 78(2), 352-360. https://doi.org/10.1095/biolreprod.107.064006
Pregnancy exposure to di(n-butyl) phthalate (DBP) in rats induces a testicular dysgenesislike syndrome (TDS) in male offspring. Earlier studies suggested altered Sertoli cell ...

The origins and time of appearance of focal testicular dysgenesis in an animal model of testicular dysgenesis syndrome: evidence for delayed testis development?

Journal Article
Hutchison, G. R., Sharpe, R. M., Mahood, I. K., Jobling, M., Walker, M., McKinnell, C., …Scott, H. M. (2008)
The origins and time of appearance of focal testicular dysgenesis in an animal model of testicular dysgenesis syndrome: evidence for delayed testis development?. International Journal of Andrology, 31(2), 103-111. https://doi.org/10.1111/j.1365-2605.2007.00816.x
A testicular dysgenesis-like syndrome is induced in rats by fetal exposure todi(n-butyl) phthalate (DBP). A key feature of this is the formation of focal dys-genetic areas com...

Consequences for the male fetus: Time windows of testosterone action and susceptibility to disorders of ‘masculinisation’

Journal Article
Sharpe, R. M., Scott, H. M., Hutchison, G., Walker, M., McKinnell, C., Saunders, P., & Welsh, M. (2007)
Consequences for the male fetus: Time windows of testosterone action and susceptibility to disorders of ‘masculinisation’. Toxicology, 240(3), 144-145. https://doi.org/10.1016/j.tox.2007.06.027
Conference abstract in Proceedings of the Annual Congress of The British Toxicology Society.

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