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73 results

Dynamic Transmission of Staphylococcus Aureus in the Intensive Care Unit

Journal Article
Adams, C. E., & Dancer, S. J. (2020)
Dynamic Transmission of Staphylococcus Aureus in the Intensive Care Unit. International Journal of Environmental Research and Public Health, 17(6), https://doi.org/10.3390/ijerph17062109
Staphylococcus aureus is an important bacterial pathogen. This study utilized known staphylococcal epidemiology to track S. aureus between patients, surfaces, staff hands and ...

Revising Nightingale's legacy

Journal Article
Dancer, S. (2020)
Revising Nightingale's legacy. Journal of Hospital Infection, 105(2), 344-345. https://doi.org/10.1016/j.jhin.2020.03.016
The recent editorial from this Journal does well to highlight the benefits of hand hygiene once again [ 1 ]. It is entirely appropriate to support the need for clean hands, es...

Measuring environmental contamination in critical care using dilute hydrogen peroxide (DHP) technology: An observational cross-over study

Journal Article
Oon, A., Reading, E., Ferguson, J., Dancer, S., & Mitchell, B. (2020)
Measuring environmental contamination in critical care using dilute hydrogen peroxide (DHP) technology: An observational cross-over study. Infection, Disease & Health, 25(2), 107-112. https://doi.org/10.1016/j.idh.2019.12.005
Background The environment has an important role in the transmission of healthcare associated infections. This has encouraged interest in novel methods to improve hygiene in h...

Design of a New Peptide Substrate Probe of the Putative Biomarker Legumain with Potential Application in Prostate Cancer Diagnosis ex vivo

Journal Article
Mathur, S., Turnbull, A., Akaev, I., Stevens, C., Agrawal, N., Chopra, M., & Mincher, D. (2020)
Design of a New Peptide Substrate Probe of the Putative Biomarker Legumain with Potential Application in Prostate Cancer Diagnosis ex vivo. International Journal of Peptide Research and Therapeutics, 26, 1965-1980. https://doi.org/10.1007/s10989-019-09994-1
The lysosomal endoprotease legumain (asparaginyl endoprotease) has been proposed as a putative biomarker in prostate tumours, in which the enzyme is markedly overexpressed. Ov...

Hand antisepsis without decreasing efficacy by shortening the rub-in time of alcohol-based handrubs to 15 seconds

Journal Article
Harnoss, J., Dancer, S., Kaden, C., Baguhl, R., Kohlmann, T., Papke, R., …Kramer, A. (2020)
Hand antisepsis without decreasing efficacy by shortening the rub-in time of alcohol-based handrubs to 15 seconds. Journal of Hospital Infection, 104(4), 419-424. https://doi.org/10.1016/j.jhin.2019.09.004
Background A previous study among neonatal intensive care unit (NICU) nurses showed that the antibacterial efficacy of alcohol-based handrubs (ABHR) can be achieved in 15 s in...

The effectiveness of home versus community-based weight control programmes initiated soon after breast cancer diagnosis: a randomised controlled trial

Journal Article
Harvie, M., Pegington, M., McMullan, D., Bundred, N., Livingstone, K., Campbell, A., …Howell, A. (2019)
The effectiveness of home versus community-based weight control programmes initiated soon after breast cancer diagnosis: a randomised controlled trial. British Journal of Cancer, 121(6), 443–454. https://doi.org/10.1038/s41416-019-0522-6
Background Breast cancer diagnosis may be a teachable moment for lifestyle behaviour change and to prevent adjuvant therapy associated weight gain. We assessed the acceptabili...

Understanding the attitudes and acceptability of extra-genital Chlamydia testing in young women: evaluation of a feasibility study

Journal Article
Brown, S., Paterson, C., Dougall, N., Cameron, S., & Wheelhouse, N. (2019)
Understanding the attitudes and acceptability of extra-genital Chlamydia testing in young women: evaluation of a feasibility study. BMC Public Health, 19(1), https://doi.org/10.1186/s12889-019-7313-0
Background Chlamydia trachomatis (C. trachomatis) is the most common bacterial sexually transmitted infection in the UK. Recent studies suggest that in addition to the genital...

Tracking Staphylococcus aureus in the intensive care unit using Whole-Genome Sequencing

Journal Article
Dancer, S. J., Adams, C. E., Smith, J., Pichon, B., Kearns, A., & Morrison, D. (2019)
Tracking Staphylococcus aureus in the intensive care unit using Whole-Genome Sequencing. Journal of Hospital Infection, 103(1), 13-20. https://doi.org/10.1016/j.jhin.2019.04.016
Background: Staphylococcus aureus remains an important bacterial pathogen worldwide. This study utilized known staphylococcal epidemiology to track S. aureus between different...

The inflammatory bowel disease drug azathioprine induces autophagy via mTORC1 and the unfolded protein response sensor PERK

Journal Article
Hooper, K. M., Casanova, V., Kemp, S., Staines, K. A., Satsangi, J., Barlow, P. G., …Stevens, C. (2019)
The inflammatory bowel disease drug azathioprine induces autophagy via mTORC1 and the unfolded protein response sensor PERK. Inflammatory Bowel Diseases, 25(9), 1481-1496. https://doi.org/10.1093/ibd/izz039
Background Genetic studies have strongly linked autophagy to Crohn's disease (CD) and stimulating autophagy in CD patients may be therapeutically beneficial. The aim of this s...

The type III intermediate filament vimentin regulates organelle distribution and modulates autophagy

Journal Article
Biskou, O., Casanova, V., Hooper, K., Kemp, S., Wright, G. P., Satsangi, J., …Stevens, C. (2019)
The type III intermediate filament vimentin regulates organelle distribution and modulates autophagy. PLOS ONE, 14(1), https://doi.org/10.1371/journal.pone.0209665
The cytoskeletal protein vimentin plays a key role in positioning of organelles within the cytosol and has been linked to the regulation of numerous cellular processes includi...

Date


31 results

False webs: Network to address the misinformation pandemic

2023 - 2025
Fake news (inaccurate information) peaked during the pandemic with around 46 000 daily Twitter posts containing false information (Lupi, 2020). In Europe over 70% people regularly encounter fake news ...
Funder: Royal Society of Edinburgh | Value: £19,931

Development of an in vitro suppression assay to assess functionality of therapeutic regulatory T cell for the treatment of rheumatoid arthritis

2023 - 2024
MRS Summer Studentship for ENU Undergrad student Martin Swapp - 8 weeks in duration over summer 2023
Funder: Medical Research Scotland | Value: £3,030

Medical Research Scotland Vacation Scholarship

2022 - 2023
Investigating the anti-metastatic potential of Honokiol by attenuating KISS1/ KISS1R signaling
Funder: Medical Research Scotland | Value: £2,160

Exploiting micofluidic devices for physiologically relavent drug screening against human pathogens

2022 - 2022
Undergraduate student summer project (8 weeks)
Funder: Medical Research Scotland | Value: £2,160

Enhancing the stability and the delivery of lactoferrin for prevention and/or treatment of covid-19 respiratory disease.

2022 - 2023
Lactoferrin (LF) is a glycoprotein which is widely contained in many secretory fluids, mainly milk but also saliva, tears, and nasal secretions. Many scientific reports supported an application of thi...
Funder: Royal Society | Value: £17,494

Does Residual Beta Cell Function and Exercise Offer Synergistic Protection Against Hyperglycaemic Induced Circulating Vasoprotective Dysfunction in Type 1 Diabetes?

2021 - 2022
For people with T1D, exercise is beneficial, potentially reducing the progression of diabetes-related complications. Many people (up to 80%) with T1D still release small amounts of insulin together wi...
Funder: Diabetes Research & Wellness Foundation

TB/COVID-19 co-infections within a 3D in vitro imaging system

2021 - 2022
TB/COVID-19 co-infections within a 3D in vitro imaging system
Funder: Animal Free Research UK | Value: £500

Developing an adoptive regulatory T cell therapy for the treatment of rheumatoid arthritis

2021 - 2024
The immune system contains a balance of cells that turn responses ‘on’ and those that turn it ‘off’. When this balance breaks down, inappropriate immune responses can attack healthy tissue...
Funder: Chief Scientists Office | Value: £229,020

Host Defence Peptides as novel modulators of autophagy in Inflammatory Bowel Disease

2019 - 2022
Increasing numbers of patients are diagnosed with inflammatory bowel disease (IBD) each year, both in the United Kingdom and worldwide. Most drugs in current use for the treatment of IBD target the im...
Funder: The Daphne Jackson Trust | Value: £83,167

EEID travel award: Understanding transmission dynamics for bacterial zoonoses in humans, goats and camels among pastoral communities in Northern Kenya

2019 - 2019
EEID travel award: Understanding transmission dynamics for bacterial zoonoses in humans, goats and camels among pastoral communities in Northern Kenya
Funder: Biotechnology and Biological Sciences Research Council | Value: £1,960